Registration Dossier
Registration Dossier
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EC number: 205-029-4 | CAS number: 131-56-6
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Title:
- Final report on the safety assessment of benzophenones-1, -3, -4, -5, -9, and -11
- Author:
- Anonymous
- Year:
- 1 983
- Bibliographic source:
- Journal of the American College of Toxicology, Volume 2, Number 5 (1983), page 35-77
Materials and methods
Test guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Principles of method if other than guideline:
- Draize
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 2,4-dihydroxybenzophenone
- EC Number:
- 205-029-4
- EC Name:
- 2,4-dihydroxybenzophenone
- Cas Number:
- 131-56-6
- Molecular formula:
- C13H10O3
- IUPAC Name:
- 4-benzoylbenzene-1,3-diol
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- other: albino
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: other eye of same animal
- Amount / concentration applied:
- 100 mg of the undiluted substance
- Duration of treatment / exposure:
- there was no eye wash
- Observation period (in vivo):
- daily for 7 days
- Number of animals or in vitro replicates:
- 6
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: day 1
- Score:
- 20
- Max. score:
- 110
- Remarks on result:
- other: In a second identical study the score was 17
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: day 2
- Score:
- 7
- Max. score:
- 110
- Remarks on result:
- other: In a second identical study the score was 15
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: day 3
- Score:
- 0
- Max. score:
- 110
- Remarks on result:
- other: In a second identical study the score was 10.3
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: day 4
- Score:
- 0
- Max. score:
- 110
- Remarks on result:
- other: In a second identical study the score was 3
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: day 5
- Score:
- 0
- Max. score:
- 110
- Remarks on result:
- other: In a second identical study the score was 0
Applicant's summary and conclusion
- Interpretation of results:
- Category 2B (mildly irritating to eyes)
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
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