Registration Dossier
Registration Dossier
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EC number: 205-016-3 | CAS number: 131-17-9
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Date of Study Report: August 25, 1976
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Basic data given: comparable to guidelines/standards
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 976
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: 16CFR 1500.40
- Deviations:
- not specified
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Diallyl phthalate
- EC Number:
- 205-016-3
- EC Name:
- Diallyl phthalate
- Cas Number:
- 131-17-9
- Molecular formula:
- C14H14O4
- IUPAC Name:
- 1,2-bis(prop-2-en-1-yl) benzene-1,2-dicarboxylate
- Test material form:
- other: liquid
- Details on test material:
- - Name of test material (as cited in study report): Diallyl phthalate
- Analytical purity: 99 %
- Other:
- Identified as C8013-3
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- other: albino
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- The acute dermal toxicity study (single exposure) was conducted on adult albino rabbits selected from healthy, acclimated animals.
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Details on dermal exposure:
- No details provided in report
- Duration of exposure:
- No details provided in report
- Doses:
- 200, 2000 and 5000 mg/kg
- No. of animals per sex per dose:
- 30 rabbits used in total (no details provided whether they were male or female)
- Control animals:
- not specified
- Details on study design:
- No details provided in report
- Statistics:
- No details provided in report
Results and discussion
- Preliminary study:
- N/A
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 3 300 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No details provided in report
- Clinical signs:
- other: No details provided in report
- Gross pathology:
- No details provided in report
- Other findings:
- No details provided in report
Any other information on results incl. tables
Results:
Dosage Level (mg/kg) |
No.*Rabbits Dosed |
Deaths |
||||||||||||||
Day |
||||||||||||||||
1 |
2 |
3 |
4 |
5 |
6 |
7 |
8 |
9 |
10 |
11 |
12 |
13 |
14 |
Mortality after 14 Days |
||
200 |
10 |
3 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
3/10 |
2000 |
10 |
1 |
0 |
0 |
1 |
0 |
0 |
0 |
1 |
0 |
0 |
0 |
1 |
0 |
0 |
4/10 |
5000 |
10 |
1 |
2 |
3 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
6/10 |
* Administered as received.
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
- Remarks:
- Migrated information
- Conclusions:
- The approximate acute Dermal LD50 obtained for the test material identified above is 3300 mg/kg of body weight estimated by interpolation from the probit response curve.
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