Registration Dossier
Registration Dossier
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EC number: 482-110-2 | CAS number: -
Endpoint summary
Administrative data
Description of key information
In the test for acute oral toxicity, the test substance was applied to outbred albino rats at dose levels of 175, 550 and 2000 mg/kg body weight. Three out of four animals dosed with 550 mg/kg died before the end of the in-life phase. Prior to death, one animal exhibited signs of toxicity like piloerection, severe tremors and cyanosis. Two animals dosed at 2000 mg/kg were found dead within four hours of test item administration. An LD50 of 550 mg/kg (confidence interval 114.7 mg/kg and 824 mg/kg) was estimated. Based on these results, the test substance has to be classified as harmful.
In the dermal toxicity study, the test substance was applied to New Zealand White rabbits at dose levels of 250, 500, 1000, 1500 and 2000 mg/kg body weight. All animals dosed with 2000, 1500 and one female dosed with 1000 mg/kg died within the first 24 hours. The surviving male dosed with 1000 mg/kg exhibited signs of lethargy and abnormal posture for the first 2 days of the study. A definitive LD50-study was not performed. Based on the results of the study, the LD50-value would be expected to be within the range of 500 - 1500 mg/kg. According to this estimation, the test substance has to be classified as harmful.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 550 mg/kg bw
Acute toxicity: via dermal route
Endpoint conclusion
- Value:
- mg/kg bw
Additional information
Justification for classification or non-classification
According to EU classification criteria, the test substance is harmful to human health.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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