Registration Dossier
Registration Dossier
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EC number: 253-168-4 | CAS number: 36727-29-4
Endpoint summary
Administrative data
Description of key information
3,5,5 trimethyhexanoyl chloride causes severe burns on the skin. This implies the possible risk of severe eye damage despite the substance was only slightly irritation to the eyes in animal testing.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (corrosive)
Additional information
skin:
In a study equivalent to an OECD TG 404, undiluted 3,5,5 trimethyhexanoyl chloride (0.5 mL) was applied to the clipped intact skin of Vienna White rabbits for 4 h (2 animals) 1 h (2 animals) and 3 min (6 animals) under occlusive conditions (BASF 1979). The animals were scored for erythema and eschar formation, edema formation and any other dermal effects or irritation at 24, 48 hours and 8 days after removal of the patch. Full thickness necrosis and scars were observed after 4 h exposure, indicating that the substance causes severe burns. Superficial, but no full thickness necrosis was observed after 1 h or 3 min exposure.
eye:
In a Draize study, 0.1 mL 3,5,5 trimethyhexanoyl chloride was applied to the eyes of three rabbits (strain not specified) (BASF, 1979). No iridal and practical no cornea reaction was noted in any of the animals at any of the examination intervals. Slight conjunctival reddening was noted in all rabbits 24 hrs after treatment. Changes were mostly reversible and on day 8 post treatment only two animlas showed slight reddening. 3,5,5 trimethyhexanoyl chloride was slightliy irritating.
Justification for classification or non-classification
Full thickness necrosis and scars were observed in 2 animals after 4 h of exposure. However, superficial, but no full thickness necrosis was observed after 1 h or 3 min of exposure. Thus, the substance is to be classified as skin corrosive Cat. 1C; H314: Causes severe skin burns and eye damage according to EU-GHS (CLP regulation).
This implies the possible risk of severe eye damage, although in vivo data does not suggest a potential for eye irritation.
Based on the skin corrosion and the inhalation toxicity of the substance the additional labeling with EUH071 (corrosive to the respiratory tract) is recommended.
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