Registration Dossier
Registration Dossier
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EC number: 253-039-2 | CAS number: 36443-68-2
Endpoint summary
Administrative data
Description of key information
Not readily biodegradable (by OECD criteria).
Additional information
The ready biodegradability of the test item was assessed over a 28 day period by the modified Sturm test (OECD 301B). The nominal test concentrations were 10 and 20 mg a.s./L. The test material attained up to 8 and 3 % biodegradation after 28 days whereas the positive control substance (Aniline) was 96 % degraded 28 days. These results indicate that the test item cannot be classified readily biodegradable under conditions of the test.
Additional QSAR calculations with Catalogic v5.12.1, Catalogic 301C v10.14 revealed a degradation of 14% after 28d. 50 metabolites were predicted and for 20 of them a quantity greater than 0.1 % was predicted. Due to low log Kow values (<4) 18 of them were not further assessed regarding their bioaccumulation potential. 2 metabolites (#9 and #31) were further assessed for their bioaccumulation potential (see 5.3.1). The main metabolite was3-(3-tert-butyl-4-hydroxy-5-methyl-phenyl)propanoic acid (#9). The substance is 100% in the applicability domain of the model.
A simulation study in water and sediment is not regarded as valid as it could not be clarified if the substance degraded or merely bound to the sludge.
The test substance was found to be poorly biodegradable in an OECD 301B study. It is assumed that the results of further simulation studies would not reveal any different findings. Therefore, further simulation studies in water/sediment and soil are not provided.
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