Registration Dossier
Registration Dossier
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EC number: 939-350-2 | CAS number: 85409-22-9
Endpoint summary
Administrative data
Description of key information
Acute and chronic aquatic toxicity test results are used in the present risk assessment. Three trophic levels (fish, daphnia, algae) are covered by the acute and chronic toxicity data set and can be used for hazard assessment. Adverse effects were observed for all trophic levels, algae appeared to be the most sensitive species as indicated by a 71-h NOErC value of 1.2 µg a.i/L (Mayer et al. 2001).
Sensitivity of daphnids seems to be in the same range with a 21-d NOEC of 4.15 µg a.i./L (McIntyre and Pate 1992).
Additional information
The freshwater algae Selenastrum capricornutum (exposed to quaternary ammonium compounds, benzyl-C12-16-alkyldimethyl, chloride) appeared to be the most sensitive group as indicated by a NOErC (72 h) value of 1.2 µg a.i./L (a growth rate inhibition of 3.1 % at this level was considered negligible), an ErC10 (71 h) of 9 µg a.i./L and an ErC50 (71 h) of 49 µg a.i./L. (Mayer et al. 2001)
Sensitivity of daphnids towards quaternary ammonium compounds, benzyl-C12-14-alkyldimethyl, chloride seems to be in the same range with a 21-d NOEC (reproduction) of 4.15 µg a.i./L. Though the study is valid, no LOEC could be determined, because 4.15 µg/L represents the highest concentration tested. Nevertheless, in the preliminary range finder study the LOEC (reproduction) was determined to be at 5.02 µg/L. (McIntyre and Pate 1992)
Also, Daphnia magna was the most sensitive organism in acute toxicity test conducted in accordance with OECD 202 displaying a 48-h EC50 of 16 µg a.i./L. (Jenkins 2007)
The acute toxicity of quaternary ammonium compounds, benzyl-C12-16-alkyldimethyl, chloride towards four different fish species (one salt- and three freshwater species) was as well evaluated, revealing the lowest 96-h LC50 of 280 µg a.i./L for the species Lepomis macrochirus. A chronic toxicity test (Fish early-life stage (FELS) toxicity test) resulted in a 28-d NOEC (survival) of 32.2 µg a.i./L.
Information on quaternary ammonium compounds, benzyl-C12-14-alkyldimethyl, chlorides is used in a read-across approach in the assessment of the substance to be registered.
For details and justification of read-across please refer to the attached report in section 13 of IUCLID.
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