Registration Dossier
Registration Dossier
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EC number: 222-981-6 | CAS number: 3687-46-5
Exposure related observations in humans: other data
Administrative data
- Endpoint:
- exposure-related observations in humans: other data
- Type of information:
- experimental study
- Adequacy of study:
- disregarded due to major methodological deficiencies
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Only short abstract available.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 970
- Report date:
- 1970
Materials and methods
- Type of study / information:
- A patch test and a Burckhardt test was performed in 5 subjects each to evaluate the acute skin irritation potential of decyl oleate.
- Endpoint addressed:
- skin irritation / corrosion
- Principles of method if other than guideline:
- A patch test and a Burckhard test was conducted.
- GLP compliance:
- no
Test material
- Reference substance name:
- Decyl oleate
- EC Number:
- 222-981-6
- EC Name:
- Decyl oleate
- Cas Number:
- 3687-46-5
- Molecular formula:
- C28H54O2
- IUPAC Name:
- decyl octadec-9-enoate
- Details on test material:
- - Name of test material (as cited in study report): Oelsaeuredecylester
- Analytical purity: no data given
Constituent 1
Method
- Details on study design:
- Patch test:
The undiluted test material, covered with a plaster, was applied onto the upper arm of 5 persons for an exposure period of 2 hours.
Burckhard test:
The undiluted test material was applied onto the forearm of 5 persons (the test material was gently rubbed into the skin in 30 sec intervals for a total of 30 min using a glass rod).
Results and discussion
- Results:
- Patch test:
During the exposure period 3/5 persons reported to feel a slight burning at the treated skin site, which was fully reversible 30 min after removing the plaster. After removal of the plaster the skin was examined for irritation. No skin reactions were observed.
Burckhard test:
During the application period until the end of the experiment, no skin reactions were seen.
Applicant's summary and conclusion
- Conclusions:
- Undiluted decyl oleate did not show a acute skin irritation potential after acute exposure up to 2 h in 10 test persons.
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