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EC number: 214-703-7 | CAS number: 1187-93-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
Eye irritation: not irritating
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no study available
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: guideline test with GLP
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- adaptation to gaseous form
- GLP compliance:
- yes
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- Two male and one female rabbits(weight range 2.5-3.0kg)were used. They were housed individually in aluminium cages with grid floors beneath which were peat moss filled trays. They were fed on Special Diet Services Rabbit Diet of satisfactory analysis and allowed food and water ad libitum. A 12 h light/dark cycle was in operation. Mean environmental maximum and minimum temperatures were 19℃ and 16℃ and mean relative humidity was 54%. The animals were allowed an acclimatisation period of 63 days before test commencement.
- Vehicle:
- not specified
- Controls:
- other: the other eye remained untreated to serve as a control
- Amount / concentration applied:
- in a single burst
- Duration of treatment / exposure:
- 1 second
- Observation period (in vivo):
- at 1, 24, 48 and 72 h after instillation
- Number of animals or in vitro replicates:
- two males and one female
- Details on study design:
- The rabbit was held firmly but gently and the right eye was held open. The test material was then administered in a single burst of about 1 s duration from a distance of 10 cm directly in front of the eye. The lids were then gently held together for 1 or 2s. The other eye remained untreated to serve as a control. The eyes were examined for irritation, using standard illumination, at 1, 24, 48 and 72h ater instillation, using the scoring system as OECD 405.
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Remarks on result:
- no indication of irritation
- Other effects:
- No discharge observed
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- It can be concluded that the test substance is non-irritant to rabbit eyes.
- Executive summary:
Two male and one female rabbits were used to conduct this acute eye irritation test. The test material was administered in a single burst of about 1 second duration .The eyes were examined for irritation. The reaction scores for cornea, iris, and conjunctivae in this test are 0. No corneal, iridial or conjunctival responses were noted. Therefore, it can be concluded that the test substance shall not be classified according to CLP (Regulation EC No.1272/2008).
Reference
See data reported in the field "Attached background material".
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Though the substance is a gas, direct eye irritation data is available, which is a well organized report of guideline testing with GLP. In this study, the test material was administered in a single burst of about 1 second duration. Two male and one female rabbits were used to conduct this acute eye irritation test, which failed to reveal the eye irritation of test substance. No corneal, iridial or conjunctival responses were observed at all animals. Therefore, it can be concluded that the test substance will not be classified according to CLP(Regulation EC No.1272/2008).
Justification for selection of skin irritation / corrosion endpoint:
In accordance with column 2 of Annex VIII - Specific rules for daptation to standard requirements, the skin irritation/corrosion studies (required in section 8.1 and 8.1.1 Annex VII and VIII) do not need to be conducted as the test substance is a flammable gas at the room temperature. In accordance with Annex XI section 1, point 2 of REACH Regulation (EC) No. 1907/2006, the skin irritation/corrosion studies are not technically possible due to technical limitations of the test methods.
Justification for selection of eye irritation endpoint:
guideline test with GLP
Justification for classification or non-classification
According to CLP regulation (Regulation EC No. 1272/2008), it is conclusive but not sufficient for classification on eye irritation.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.

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