Registration Dossier
Registration Dossier
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EC number: 913-888-8 | CAS number: -
Endpoint summary
Administrative data
Description of key information
Based on reliable in vivo studies with ammonium dihydrogenorthophosphate showing no or minimal irritation and an in vitro eye irritation study with diammonium hydrogenorthophosphate, it is concluded that the reaction mass is not irritating to skin and eyes.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
Skin irritation
In a reliable skin irritation study performed comparable to OECD 404 guideline, ammonium dihydrogenorthophosphate does show some effects on the erythema, which are minimal and fully reversible within 72 hours. No reliable study on diammonium hydrogenorthophosphate is present.
Eye irritation
In a reliable eye irritation study performed comparable to OECD 405 guideline, ammonium dihydrogenorthophosphate does not show any effects on the cornea and iris, but does show some limited effects on the conjunctiva (score 1 out of 3). These were decreasing in time, however not fully reversible within 72 hours (in 2 out of 6 animals). Because reversibility of the findings is expected due to the trend obvious in the individual data, the substance is considered as a non-irritant. An in vitro Bovine Corneal Opacity and Permeability test (OECD 437 guideline) showed that diammonium hydrogenorthophosphate is a not an irritant under the test conditions. In addition, no reliable in vivo studies on diammonium hydrogenorthophosphate are present.
Justification for classification or non-classification
Based on the available data on the two components, the reaction mass of ammonium dihydrogenorthophosphate and diammonium hydrogenorthophosphate does not have to be classified according to Directive 67/548/EC and the CLP Regulation for skin and eye irritation.
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