Registration Dossier
Registration Dossier
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EC number: 252-161-3 | CAS number: 34708-08-2
Endpoint summary
Administrative data
Description of key information
Additional information
Reliable short-term toxicity test results are available for the registered substance, triethoxy(3-thiocyanatopropyl)silane (CAS 34708-08-2; EC No. 252-161-3), for freshwater fish (Danio rerio, reported as Brachydanio rerio), invertebrates (Daphnia magna) and algae (Desmodesmus subspicatus, reported as Scenedesmus subspicatus). The relevant short-term values are:
Fish: LC50 (96 h): between 10 and 18 mg/l (nominal), expressed in terms of the concentration of the parent substance;
Invertebrate: EC50 (24 h): 29 mg/l (nominal), expressed in terms of the concentration of the parent substance;
Algae: ErC50 (96 h): 160 mg/l; NOErC: 32 mg/l (nominal), expressed in terms of the concentration of the parent substance.
Reliable long-term toxicity test results are not currently available, however there are ongoing studies for the long-term fish and aquatic invertebrates endpoints, conducted according to OECD TG 210 and 211, respectively, and in accordance with GLP. The PNECaquatic will be updated once the results of these studies become available.
An activated sludge respiration inhibition 3-hour EC50 value of 130 mg/l and an EC10 value of 4.2 mg/l (loading rate, nominal) were determined in a reliable study. It was not possible to determine a NOEC value in the study (NOEC was <1.0 mg/l (loading rate, nominal)).
The registered substance is susceptible to hydrolysis reactions, as described in Section 5.1.2 of IUCLID. Therefore it is likely that, in the available aquatic studies, the test organisms were exposed to a mixture of the hydrolysis products of the substance and the test substance. A functional group associated with ecotoxicity by a specific mode of action (thiocyanate) is present in both the registration substance and the silanol hydrolysis product, and the effects seen are attributed to this. It is therefore reasonable to conclude that both the parent and hydrolysis product could contribute to any effects observed.
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