Registration Dossier
Registration Dossier
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EC number: 265-100-0 | CAS number: 64741-99-7 A complex combination of hydrocarbons obtained as the extract from a solvent extraction process. It consists predominantly of aromatic hydrocarbons having carbon numbers predominantly in the range of C6 through C8 and boiling in the range of approximately 80°C to 145°C (176°F to 293°F). This stream is likely to contain 10 vol. % or more benzene.
Neurotoxicity
Administrative data
Description of key information
There are no specific neurotoxicity data on any of the streams within the High Benzene Naphtha category. Of the specific constituents present in some streams toluene and n-hexane are recognised as having neurotoxic activity. These effects are briefly discussed in the section on repeated dose toxicity (5.6.3).
Key value for chemical safety assessment
Additional information
Toluene exposure can produce central nervous system pathology in animals after high oral doses. In humans neuropsychological effects have been reported, particularly when exposures are not well controlled. There was no evidence that long-term exposure to toluene at 26 ppm for 21 years had any effects on cognitive function (Seeber et al, 2004).
In animals following oral or inhalation exposure n-hexane can produce neurologic dysfunction of motor or sensorimotor nerves resulting in weight loss and paralysis (Spencer and Schaumberg, 1985). Epidemiological studies on n-hexane have shown an association between inhalation exposure to n-hexane and neurological symptoms in occupationally exposed individuals. The NOAEC for peripheral neuropathy is reported to be 20 ppm (70 mg/m3) (UK HSE, 1990).
Reference
UK HSE (1990). N-Hexane occupational exposure standard. UK HSE Review 1990, D34-D35, Published 1993
Justification for classification or non-classification
See section 5.6 for overall classification for repeated dose toxicity.
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