Registration Dossier
Registration Dossier
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EC number: 219-314-6 | CAS number: 2409-55-4
Toxicological Summary
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Acute/short term exposure
DNEL related information
Local effects
Acute/short term exposure
DNEL related information
Workers - Hazard via dermal route
Systemic effects
Acute/short term exposure
DNEL related information
Workers - Hazard for the eyes
Additional information - workers
no valid repeated dose studyand no acute toxicity study for dermal and inhaltive toxicity are available. 2-tert-butyl-m-cresol is classified (self classification) as corrosive and the substance is irritating to the skin and higly irritating to the eye. A DNEL (inhalative or dermal) for long term or acute/short-term exposure for local and systemic effects is therefore not quantifiable.
2 -tert-butyl-p-cresol is classified as corrosive and shall be registrated according REACH Article 18 (transported isolated intermediate) and testing is not justified on scientific and animal welfare grounds.
However, a qualitative assessment for risk charakterisation can be done. Substances with the R-phrase R34 (causes burns) are allocated to the moderate hazard category, on the basis that exposure should be well controlled (see RIP Part E: Risk characterisation, page 25).
Risk Management Measures and Operational conditions:
a) General: - containment as appropriate; -minimise number of staff exposed; -segregation of the emitting process; -effective contaminant extraction; -good standard of general ventilation; -minimisation of manual phases; - avoidance of contact with contaminated tools and objects; - regular cleaning of equipment and working area; - management/ supervision in place to check that RMMs in place are being used correctly and OCs followed; - training for staff on good practice; - good standard of personel hygiene
b) PPE: - substance/task appropriate gloves; - skin coverage with appropriate barrier material based on potential for contact with the chemicals; - substance/task appropriate respirator; optional face shield; - eye protection; - chemical goggles
General Population - Hazard via inhalation route
Systemic effects
Acute/short term exposure
DNEL related information
Local effects
Acute/short term exposure
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Acute/short term exposure
DNEL related information
General Population - Hazard via oral route
Systemic effects
Acute/short term exposure
DNEL related information
General Population - Hazard for the eyes
Additional information - General Population
2-tert-butyl shall be registrated according REACH Article 18 (transported isolated intermediate). The general population is therefore not exposed to this material
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
