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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Developmental toxicity / teratogenicity

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Administrative data

Endpoint:
developmental toxicity
Type of information:
(Q)SAR
Adequacy of study:
supporting study
Rationale for reliability incl. deficiencies:
other: OECD Toolbox Category Approach based on data from 17 related substances.
Justification for type of information:
QSAR prediction: migrated from IUCLID 5.6

Data source

Reference
Reference Type:
other: OECD Toolbox
Title:
Guidance Document on the Validation of (Quantitative) Structure-Activity Relationships Models
Author:
OECD
Year:
2007
Bibliographic source:
OECD, Publisher. September, 2007

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
The OECD Toolbox Category Approach was used and the OECD profilers for DNA OASIS and Estrogen Receptor Binding were calculated. Reproductive and developmental toxicity endpoints were of interest for this analysis. They included teratogenicity, gene mutation, chromosomal aberration, and relative ERBA.

Test material

Constituent 1
Chemical structure
Reference substance name:
Allantoin
EC Number:
202-592-8
EC Name:
Allantoin
Cas Number:
97-59-6
Molecular formula:
C4H6N4O3
IUPAC Name:
1-(2,5-dioxoimidazolidin-4-yl)urea

Results and discussion

Results (fetuses)

Fetal abnormalities

Abnormalities:
not specified

Overall developmental toxicity

Developmental effects observed:
not specified

Applicant's summary and conclusion