1,2-dichlorobenzene

Additional toxicological data

Administrative data

Endpoint:

additional toxicological information

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Basic data given

Cross-reference

Reason / purpose for cross-reference:

reference to same study

Data source

Reference

Title:

No information

Author:

De Ceaurriz, J. et al.: J. Appl. Toxicology 8, 417-422|(1988)

Materials and methods

Type of study / information:

Type: other

Principles of method if other than guideline:

Whole-body exposure to o-dichlorobenzene vapours for 4 hours. Tubular toxicity and centrilobular liver demage were evaluated histochemically from the enumeration of damaged proximal tubules in cryostat kidney sections stained for alkaline phosphatase and the measurement of centrilobular glucose-6-phosphatase.

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

1,2-dichlorobenzene

EC Number:

202-425-9

EC Name:

1,2-dichlorobenzene

Cas Number:

95-50-1

Molecular formula:

C6H4Cl2

IUPAC Name:

1,2-dichlorobenzene

Results and discussion

Any other information on results incl. tables

Table1. Effect of o-dichlorobenzene (DCB) (15 minutes exposure) on the respiratory rate of mice

		Respiratory rate
Test compound	Exposure concetration^a (ppm)	Before exposure^b	During exposure^b (breaths/min)	Percentage decrease
DCB		(breaths/min)
	116	240 ± 11.6	177 ± 11.3*	26
	153	253 ± 5.7	139 ± 8.8*	45
	196	266 ± 17.0	121 ± 17.0*	55
	273	249 ± 7.2	81 ± 4.1*	68

^a The exposure concentrations are the average of the three samples taken during each 15 min exposur period, with a coefficient of varaition of < 10%.

^b The values given are the mean respiratory rate   ± SEM obtained from six mice.

^* Signifcantly different from pre-exposure level: p < 0.05