Registration Dossier
Registration Dossier
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EC number: 202-425-9 | CAS number: 95-50-1
Repeated dose toxicity: other routes
Administrative data
- Endpoint:
- repeated dose toxicity: other route
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well-documented study report which meets basic scientific principles
Data source
Reference
- Title:
- No information
- Author:
- Reustle, J.A. and Scribner, H.E. (1979): o-Dichlorobenzene;|Myelotoxicity and cytogenetic study in rats. Report of the|Toxicology Department, Rohm and Haas Company, Spring House,|Pennsylvania. EPA/OTS Doc. No. 878212182, 1-71
Materials and methods
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 1,2-dichlorobenzene
- EC Number:
- 202-425-9
- EC Name:
- 1,2-dichlorobenzene
- Cas Number:
- 95-50-1
- Molecular formula:
- C6H4Cl2
- IUPAC Name:
- 1,2-dichlorobenzene
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: COBS-CD (SD) Br
- Sex:
- male
Administration / exposure
- Route of administration:
- subcutaneous
- Duration of treatment / exposure:
- 16 d
- Frequency of treatment:
- daily
Doses / concentrations
- Remarks:
- Doses / Concentrations:
40, 200 or 1000 mg/kg bw/d
- Details on study design:
- Post-exposure period: no
Results and discussion
Effect levels
- Dose descriptor:
- NOAEL
- Effect level:
- 40 mg/kg bw/day
- Sex:
- male
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
All dose levels: no myelotoxic or cytogenetic effects
(no significant chromosomal damage to bone marrow cells observable).
200 and 1000 mg/kg bw/d: significant increases in relative liver weights.
1000 mg/kg bw/d: increased mortality and decreased body weight gain.
Applicant's summary and conclusion
- Conclusions:
- All dose levels: no myelotoxic or cytogenetic effects (no significant chromosomal damage to bone marrow cells observable). 200 and 1000 mg/kg bw/d: significant increases in relative liver weights. 1000 mg/kg bw/d: increased mortality and decreased body weight gain.
- Executive summary:
All dose levels: no myelotoxic or cytogenetic effects (no significant chromosomal damage to bone marrow cells observable).
200 and 1000 mg/kg bw/d: significant increases in relative liver weights.
1000 mg/kg bw/d: increased mortality and decreased body weight gain.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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