Registration Dossier
Registration Dossier
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EC number: 251-646-7 | CAS number: 33703-08-1
Hydrolysis
Administrative data
Link to relevant study record(s)
Description of key information
Hydrolysis is not expected to be a relevant degradation pathway since the substance is readily biodegradable.
Key value for chemical safety assessment
Additional information
In accordance with Annex VIII, column 2 (9.2.2.1) of Regulation (EC) No. 1907/2006, the testing for hydrolysis as a function of pH is not required as the substance is readily biodegradable. Furthermore, in accordance with Annex XI, subitem 2. Testing is technically not possible, of Regulation (EC) No. 1907/2006, testing for hydrolysis as a function of pH may be omitted, if the test is technically not possible to conduct. The substance is expected to be very poorly soluble in water. Thus, the test is technically not possible to conduct since the practical insolubility of the test substance impedes a proper analytics.
Generally, QSAR calculations (DT50 [pH 7] > 1 yr; HYDROWIN v2.00) and experimental data for a structurally very similar substance (Dibutyl adipate, DT50 [pH 7] > 1850 d) clearly confirms, that hydrolysis represents a negligible pathway for the environmental fate of the substance in the environment. This assumption of lack of relevance of abiotic degradation is in line with the assessment of substances as defined by the US-EPA "Aliphatic Diester Category" (US-EPA, 2010).
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