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Physical & Chemical properties

Dissociation constant

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Description of key information

Dissociation constant (3-chloropropyl)dimethoxymethylsilane: Not Relevant
Dissociation constant (silanol hydrolysis product): ca. 12

Key value for chemical safety assessment

Additional information

The requirement to test the substance for dissociation constant is waived because in contact with water the substance hydrolyses rapidly. The hydrolysis products in this case are (3-chloropropyl)methylsilanediol and methanol. There are no reliable measured data for the dissociation constant of (3-chloropropyl)methylsilanediol. The typical dissociation constants for the hydroxyl protons of silanediols are available from studies in other silanediols. It is appropriate to read-across dissociation constant data for (3-chloropropyl)methylsilanediol from dimethylsilanediol. This suggests that silanols are not expected to undergo significant dissociation within the range of pH relevant in the environment or in vivo. Dimethylsilanediol is reported in a secondary source to have a first dissociation constant of 11.9. Additional information is given in a supporting report (PFA 2013b) attached in Section 13 of the REACH technical dossier.

PFA 2013b: Peter Fisk Associates, Dissociation constant Analogue report. PFA.300.001.001.