Trichlorooctylstannane

Endpoint summary

Description of key information

Eye irritation, 001: A primary irritation index of 80 for the cornea, 10 for the iris, and 16.8 for the conjunctivae of the rabbit eye was recorded in the study. These values corresponds to the highest values according to the scoring system. The mean scores at 24, 48 and 72 hours are 4 and 2 for the cornea and iris respectively according to the scoring system, these value are greater than the values stated in the DSD (67/548/EEC) and CLP (1272/2008) regulations, and therefore the test substance will be classified accordingly. It should also be noted that the effects had not reversed by 7 days.
Skin irritation, 001: No erythema was observed in any animals at 24 or 72 hours. Edema formation was noted in all 6 animals, the mean 24 and 72 hour edema scores were 3.33 and 2.17 respectively. Although there are no 48 hour scores recorded it is considered that the 48 hour scores would not have been any lower than the 72 hour scores. With this in mind the mean edema score would be considered to greater than the the values stated in the DSD (67/548/EEC) and CLP (1272/2008) regulations, and therefore the test substance will be classified accordingly. It should also be noted that effects had not reversed by 7 days.

Key value for chemical safety assessment

Skin irritation / corrosion

Endpoint conclusion

Endpoint conclusion:

adverse effect observed (irritating)

Eye irritation

Endpoint conclusion

Endpoint conclusion:

adverse effect observed (irritating)

Additional information

The eye irritation potential of octyltin trichloride was investigated in 6 New Zealand white rabbits. The cornea was scored on the basis of degree of opacity, and area involved. The iris was scored for the presence of folds, congestion, swelling, circumcorneal injection, reaction to light, hemorrhage and gross destruction. The conjunctivae were scored for redness, chemosis, and discharge. The maximum scores for the cornea, iris, and conjunctivae were 80, 10, and 20, respectively. Trichlorooctylstannane had a primary irritation index of 80 for the cornea, 10 for the iris, and 16.8 for the conjunctivae. Therefore, it was considered a severe irritant to the rabbit eye.

The dermal irritation potential of octyltin trichloride was investigated in 6 New Zealand white rabbits. Skin reactions were scored on a scale of 0 - 4 for erythema and eschar formation as well as edema. An average of all 6 animals for intact and abraded skin at 24 and 72 hours was calculated (primary dermal irritation index). The test sites did not show any erythema, but showed necroses and edema. Symptoms did not disappear or diminish during the 7 -day observation period. Octyltin trichloride had a primary dermal irritation index of 1.4 in rabbits which was characterised as a slight irritant to the skin of rabbits.

Effects on skin irritation/corrosion: slightly irritating

Effects on eye irritation: highly irritating

Justification for classification or non-classification

On the basis of the eye scores, trichlorooctylstannane is considered an eye irriant, with risk of serious damage to eyes. Particularly obvious is the cornea, which achieved the maximum score of 80. Trichlorooctylstannane is therefore classified as Xi; R41 according to the DSD and a category 1 eye irritant according to the CLP with a danger signal word and hazard phrase H318.

On the basis of the edema response, trichlorooctylstannane is considered a skin irritant. The mean oedema score is 2.75, which classifies trichlorooctylstannane as a skin irritant according to the DSD (67/548/EEC) and 5/6 rabbits have mean odema scores >2.3

which classifies trichlorooctylstannane as a skin irritant according to the CLP (1272/2008) regulations.

Therefore, according to the DSD, trichlorooctylstannane should be classified Xi; R38 and as a category 2 irritant under the CLP with the H315 hazard phrase and warning signal word.