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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

Currently viewing:

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
migrated information: read-across based on grouping of substances (category approach)
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Narcotic and Toxic Potency of Aliphatic Alcohols upon Rabbits
Author:
Munch JC and Schwartze EW
Year:
1925
Bibliographic source:
J. Lab. Clin. Med., 10:985
Reference Type:
secondary source
Title:
Narcotic and toxic potency of aliphatic alcohols upon rabbits
Author:
Munch JC and Schwartze EW
Year:
1972
Bibliographic source:
Ind. Med. 41, 31-33
Reference Type:
secondary source
Title:
No information
Author:
RIFM
Year:
2009
Bibliographic source:
RIFM database
Reference Type:
secondary source
Title:
No information
Author:
NIOSH
Year:
2008
Bibliographic source:
RTECS

Materials and methods

Principles of method if other than guideline:
acute oral toxicity study
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Details on test material:
- Name of test material (as cited in study report): Isoamylalcohol

Test animals

Species:
rabbit
Strain:
not specified
Sex:
male/female
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Source: from regular dealers
- Weight at study initiation: 1.5 - 2.5 kg
- Fasting period before study: alfalfa hay and oats ad libitum, and carrots were offered several times a week.

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
physiological saline
Details on oral exposure:
VEHICLE
- Amount of vehicle (if gavage): 5 ml
Doses:
no data
No. of animals per sex per dose:
no data
Control animals:
not specified
Details on study design:
- Duration of observation period following administration: 24 h
- Frequency of observations and weighing: continual observation
- Necropsy of survivors performed: no
- Other examinations performed: clinical signs

Results and discussion

Effect levelsopen allclose all
Sex:
male/female
Dose descriptor:
LD50
Effect level:
3 438 mg/kg bw
Remarks on result:
other: calculated
Sex:
male/female
Dose descriptor:
LD50
Effect level:
39 other: mmol/kg bw

Any other information on results incl. tables

Narcotic Dose (ND50) of 8 mmol/kg bw was determined as that quantity producing stupor, loss of voluntary movements in half of the rabbits.

Applicant's summary and conclusion