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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
year of publication: 1974
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: insufficiently documented literature data (actual test concentration not mentioned, no information on clinical observations, body weight etc.), not in accordance with existing guidelines (e.g. exposure duration only 1 hour instead of 4 hours)

Data source

Reference
Reference Type:
publication
Title:
Industrial experience with 3,3'-dichlorobenzidine. An epidemiological study of a chemical manufacturing plant.
Author:
Gerarde HW, Gerarde DF
Year:
1974
Bibliographic source:
J. Occup. Med. 16: 322-344
Report date:
1974

Materials and methods

Principles of method if other than guideline:
acute inhalation toxicity
GLP compliance:
no
Test type:
other: acute inhalation toxicity
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
3,3'-dichlorobenzidine dihydrochloride
EC Number:
210-323-0
EC Name:
3,3'-dichlorobenzidine dihydrochloride
Cas Number:
612-83-9
Molecular formula:
C12H10Cl2N2.2ClH
IUPAC Name:
3,3'-dichloro-[1,1'-biphenyl]-4,4'-diamine dihydrochloride

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male/female

Administration / exposure

Route of administration:
inhalation: dust
Type of inhalation exposure:
not specified
Vehicle:
not specified
Details on inhalation exposure:
- particle size ranged from < 2.1 to > 21.0 µm
- about 50% of the particles were < 5 µm
Analytical verification of test atmosphere concentrations:
not specified
Duration of exposure:
1 h
Concentrations:
"concentrated dust"
No. of animals per sex per dose:
10 animals of both sexes
Control animals:
not specified

Results and discussion

Any other information on results incl. tables

Slight to moderate pulmonary congestion was observed at gross pathology. One animal had a pulmonary abscess.

Applicant's summary and conclusion

Conclusions:
Exposure of rats to concentrated dust of the test item for one hour resulted in slight to moderate pulmonary congestion. One animal had a pulmonary abscess.
Executive summary:

Exposure of rats to concentrated dust of the test item for one hour resulted in slight to moderate pulmonary congestion. One animal had a pulmonary abscess.