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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

A LOAEL of 5 mg/kg/day was derived.

Key value for chemical safety assessment

Repeated dose toxicity: via oral route - systemic effects

Endpoint conclusion
Dose descriptor:
5 mg/kg bw/day

Additional information

In a 2-year carcinogenicity study in which groups of 60 male and 60 female rats were fed diets containing TDCP to achieve dose levels of 0, 5, 20 and 80 mg/kg/day for 24 months, significantly greater mortality was recorded for high dose males. There was a clear adverse effect on body weight in the 80 mg/kg/day groups throughout the study, with body weights at termination >20 % lower than controls. A significant reduction in red blood cell parameters was noted for high-dose animals. Absolute and relative kidney, liver and thyroid weights were also increased in mid- and high-dose animals.

A LOAEL of 5 mg/kg/day (based on the hyperplasia, considered a pre-neoplastic lesion, observed in the kidneys in all treated groups and the testicular effects observed at this dose) can be derived from this study.

In a 90-day study to investigate the possible neurotoxicity of TDCP in hens, doses of 0. 4, 20 and 100 mg/kg/day TDCP were administered to hens. There were no mortalities in TDCP-treated birds. Under the conditions of the test, there was no evidence of TDCP induced delayed neurotoxicity. In an epidemiology study carried out in a TDCP manufacturing plant as an adjunct to a mortality study, no adverse health effects linked to TDCP exposure were determined.

No data are available on inhalation and dermal repeated dose toxicity.

Repeated dose toxicity: via oral route - systemic effects (target organ) digestive: liver; glandular: thyroids; urogenital: kidneys

Justification for classification or non-classification

The above data do not suggest to classify TDCP for repeated dose toxicity