Icosan-1-ol

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1987

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1987

Report date:

1987

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

GLP compliance:

yes

Test material

Test material information

Constituent 1

Reference substance name:

Docosan-1-ol

EC Number:

211-546-6

EC Name:

Docosan-1-ol

Cas Number:

661-19-8

Molecular formula:

C22H46O

IUPAC Name:

docosan-1-ol

Test animals

Species:

rat

Strain:

Sprague-Dawley

Sex:

male/female

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

other: 0.8% hydroxypropyl-methylcellulose gel

Doses:

8250 and 10000 mg/kg

No. of animals per sex per dose:

10

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

> 10 000 mg/kg bw

Any other information on results incl. tables

MORTALITY: All animals survived the 14 day observation period.

CLINICAL SIGNS: No clinical signs of toxicity. There was no adverse  effect on food intake or bodyweight gain.

NECROPSY FINDINGS: Unremarkable.

POTENTIAL TARGET ORGANS: None identified.

SEX-SPECIFIC DIFFERENCES: None

Applicant's summary and conclusion

Interpretation of results:

GHS criteria not met

Conclusions:

The rat oral LD50 for Nacol 22 RD is >10g/kg. At this dose level there was no evidence of toxicity in any of the parameters monitored.