Allyl methacrylate

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1975

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Equivalent or similar to OECD guideline, non GLP.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1975

Report date:

1975

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

Deviations:

not specified

Principles of method if other than guideline:

After 24 hours of fasting groups of 10 male albino (CF Nelson) rats were dosed with a 10% (w/v) corn oil dispersion of the product at each of four concentrations: 157, 313, 625, and 1250 mg/kg. Animals were observed for signs of intoxication and mortality at dosing, 6 and 24 hours post-dosing, and daily thereafter for 14 days. Necropsies were performed on all survivors.

GLP compliance:

no

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Allyl methacrylate

EC Number:

202-473-0

EC Name:

Allyl methacrylate

Cas Number:

96-05-9

Molecular formula:

C7H10O2

IUPAC Name:

allyl methacrylate

Test material form:

other: liquid

Test animals

Species:

rat

Strain:

other: CF Nelson (albino)

Sex:

male

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Fasting period before study: 24 h

Administration / exposure

Route of administration:

oral: unspecified

Vehicle:

corn oil

Remarks:

10% (w/v) dispersion

Details on oral exposure:

Animals were dosed with a 10.0 % (w/v) corn oil dispersion of the product.

Doses:

157, 313, 625 and 1250 mg/kg

No. of animals per sex per dose:

10 male animals

Control animals:

no

Details on study design:

- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Animals were observed for signs of intoxication and mortality at dosing, 6 and 24 hours post-dosing, and daily thereafter for 14 days.
- Necropsy of survivors performed: yes

Statistics:

no data

Results and discussion

Preliminary study:

no data

Effect levels

Sex:

male

Dose descriptor:

LD50

Effect level:

470 mg/kg bw

Based on:

test mat.

Remarks on result:

other: 350-640 mg/kg bw

Mortality:

157 mg/kg: 0/10;
313 mg/kg: 2/10;
625 mg/kg: 7/10;
1250 mg/kg: 10/10;

Clinical signs:

other: Lacrimation noted in animals at the 1250 mg/kg dose group and piloerection was noted in animals at 1250, 625 and 313 mg/kg dose groups.

Gross pathology:

Necropsy findings noted in the survivors included: irregular dark yellow liver lesions, all animals had adhesions of the stomach (primarily) and/or liver to peritoneum.

Any other information on results incl. tables

In a standard acute oral toxicity test equivalent to OECD 401 10 mal CF Nelson (albino rats) were exposed to 157, 313, 625 and 1250 mg/kg Oral LD50 was 470 mg/kg. Necropsy findings noted in the survivors included: irregular dark yellow liver lesions, all animals had adhesions of the stomach (primarily) and/or liver to peritoneum.

NOTE: Any of data in this dataset are disseminated by the European Union on a right-to-know basis and this is not a publication in the same sense as a book or an article in a journal. The right of ownership in any part of this information is reserved by the data owner(s). The use of this information for any other, e.g. commercial purpose is strictly reserved to the data owners and those persons or legal entities having paid the respective access fee for the intended purpose.

 

Applicant's summary and conclusion

Interpretation of results:

Toxicity Category IV

Remarks:

Migrated information Criteria used for interpretation of results: other: CLP, EU GHS (Regulation (EC) No 1272/2008)

Conclusions:

Under the conditions of the study the oral LD50 was 470 mg/kg for Allyl Methacrylate.

Executive summary:

In a standard acute oral toxicity test equivalent to OECD 401 10 mal CF Nelson (albino rats) were exposed to 157, 313, 625 and 1250 mg/kg Oral LD50 was 470 mg/kg. Necropsy findings noted in the survivors included: irregular dark yellow liver lesions, all animals had adhesions of the stomach (primarily) and/or liver to peritoneum.

NOTE: Any of data in this dataset are disseminated by the European Union on a right-to-know basis and this is not a publication in the same sense as a book or an article in a journal. The right of ownership in any part of this information is reserved by the data owner(s). The use of this information for any other, e.g. commercial purpose is strictly reserved to the data owners and those persons or legal entities having paid the respective access fee for the intended purpose.