Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-542-8 | CAS number: 108-01-0
Endpoint summary
Administrative data
Description of key information
Additional information
Short-term aquatic toxicity tests are available for three trophic levels (fish, invertebrates, and algae). No chronic experimental data are available regarding possible effects of the test substance.
Regarding short-term toxicity to fish, Leuciscus idus was used in two different experiments. In the key study performed according to German Industrial Standard DIN 38412 (part 15), a LC50 value (96 h) of 146.63 mg/L is reported (BASF AG, 1990). Referring to the supporting study (toxicity screening study), a LC50 (48h) range of 1500 - 2500 mg/L was determined (BASF AG, 1977).
For assessing the acute toxicity towards invertebrates, the effects on Daphnia magna according to Directive 79/831/EEC, Annex V, C2 (1984) have been determined. As final result, an EC50 (48h) of 98.37 mg/L is reported (BASF AG, 1988).
The aquatic toxicity towards algae was investigated by fluorimetric determination of algae growth exposed to dimethylethanolamine (DMAE) for 72 hours. The following results were obtained: EC50 (72h) = 66.08 mg/L, EC10 (72h) = 24.49 mg/L, and EC20 (72h) = 34.47 mg/L (BASF AG, 1989).
Referring to the toxicity of dimethylaminoethanol (DMAE) towards aquatic microorganisms, no experimental data are available. However, read-across to the substance 2,2´-(methylimino)diethanol (MDEA) was performed due to the structural similarities of both the target and the read-across substance. For the read-across substance, three valid studies are available.
In the key study, domestic activated sludge was used for an experiment conducted similar to OECD 209 (BASF AG, 1993). As final result, an EC20 (30min) greater than 1000 mg/L is reported which is based on the respiration rate. Referring to supporting information, Pseudomonas putida was used in a test conducted according to DIN 38412, part 8 (BASF AG, 1988). A photometric determination at 436 nm was used to indicate growth inhibition. The results are given as follows: EC10 (17h) = 273.8 mg/L, EC50 (17h) = 413.8 mg/L, and EC90 (17h) = 820.2 mg/L. In another supporting study, an oxygen consumption inhibition test was performed with activated sludge from BASF wastewater treatment plant (BASF AG, 1988). 1000 mg/L was the highest test concentration with less than 20 % respiration inhibition during 30 minutes exposure time. Therefore, EC20 (30 min) > 1000 mg/L is reported as effect concentration result.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
