Linalyl acetate

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: well documented study report which meets basic scientific principles

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1969

Report date:

1969

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 403 (Acute Inhalation Toxicity)

Principles of method if other than guideline:

BASF-test according to internal SOP
Principle of the method:
This test (also called inhalation risk test) was performed in principle as described in OECD Guideline 403.
It demonstrates the toxicity of an atmosphere saturated with vapors of the volatile components of a test substance at the temperature chosen for vapor generation at 20° C and 100°C.
The study allows for an estimate of the length of time required to cause severe toxic effects resulting from exposure to an atmosphere saturated with volatile components of the test substance.

GLP compliance:

no

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Linalyl acetate

EC Number:

204-116-4

EC Name:

Linalyl acetate

Cas Number:

115-95-7

Molecular formula:

C12H20O2

IUPAC Name:

1,5-dimethyl-1-vinylhex-4-en-1-yl acetate

Details on test material:

- Name of test material (as cited in study report): 3,7-dimethyl-1,6-octadien-3-yl-acetate (linalyl acetate),
- Analytical purity: 95-99%
- Impurities (identity and concentrations): dihydrolinalyl acetate

Test animals

Species:

rat

Strain:

not specified

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Weight at study initiation: mean body weights: 233 g (study group at 20°C test condition); 184.5 g (study group at 100°C test condition)

Administration / exposure

Route of administration:

inhalation: vapour

Type of inhalation exposure:

whole body

Details on inhalation exposure:

GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Temperature in air chamber: 20°C and 100°C
- Source and rate of air: 200 l/hour

Analytical verification of test atmosphere concentrations:

no

Duration of exposure:

8 h

Concentrations:

test at 20°C: no substance weight loss observed
test at 100°C: 18.94 mg/l air (mean substance concentration calculated over 8 hours)

No. of animals per sex per dose:

12 animals (sex not specified)

Control animals:

no

Details on study design:

- Duration of observation period following administration: 7 days
- Frequency of observations: not specified
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight

Results and discussion

Mortality:

No mortality was observed when 12 rats each were exposed for 8 hours to an atmosphere that had been saturated at either 20 or 100 degrees Centigrade with the volatile parts of the compound (vapour).

Clinical signs:

other: 20°C test: no symptoms observed 100°C test: slight mucous membrane irritation, elevated breathing; day 1: nothing abnormal detected

Gross pathology:

20°C test: slight bronchitis
100°C test: nothing abnormal detected