Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 225-383-3 | CAS number: 4813-57-4
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
In a chronic toxicity test to Daphnia magna STRAUSS of the read across
substance C12/ C14 acrylate, (mixture of CAS no. 2156-97-0 and
21643-42-5) the 21d-NOEC was laid down as 100 mg/L. The LOEC after 21
hours was > 100 mg/L. All effect levels are given based on the nominal
level of the test item. Therefore the test substance was found to cause
no toxic effects to Daphnia magna after 21 days when tested with a
loading level of 100 mg/L.
Based on this result the LOEC value of 2-Propenoic acid, octadecyl ester
is also considered to be >100 mg/L.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 100 mg/L
Additional information
A semi-static Daphnia magna reproduction test was performed in closed test vessels according to OECD Guideline 211 (2008) and EU Method C.20 (2008). At this method Daphnia magna, aged lower or equal 24 h at the beginning of the test, are exposed to a range of a read across substance C12/ C14 acrylate (mixture of CAS no. 2156-97-0 and 21643-42-5) under defined conditions over a period of 21 days. In the definitive limit test the nominal concentration was 100 mg/L. The read across substance C12/ C14 acrylate (mixture of CAS no. 2156-97-0 and 21643-42-5) is poorly water soluble and volatile; therefore a saturated stock solution was prepared using a liquid-liquid saturator technique. Concentration control analysis was not performed since the analytical detection limit was above the water solubility of the test substance. However, all reasonable efforts were taken to produce a saturated solution of the test substance in test media, following the guidance in OECD 23 (2000).
The following overall effect concentrations (mg/L) were obtained based on nominal concentrations: LOEC > 100 mg/L NOEC ≥ 100 mg/L No significant effect on mortality (21 d EC0 ≥ 100 mg/L) and reproduction or any adverse effects on additional endpoints (i.e. growth, immobile young, time to first brood, or aborted eggs) were observed in any of the test treatments.
Based on this result the LOEC value of 2-Propenoic acid, octadecyl ester is also considered to be >100 mg/L.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
