Registration Dossier
Registration Dossier
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EC number: 211-670-0 | CAS number: 683-18-1
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
The following studies are available for the long-term toxicity to aquatic invertebrates endpoint and are included in support of the argument for the omission of this study:
Lapota D et al (1993). Growth and survival of Mytilus edulis larvae exposed to low levels of dibutyltin and tributyltin. Marine Biology 115, 413-419.
St-Jean SD et al (2002a). Very low levels of waterborne butyltins modulate hemocyte function in the blue mussel Mytilus edulis. Mar. Ecol. Prog. Ser. 236: 155-161.
St-Jean SD et al (2002b). Hemocyte functions and bacterial clearance affected in vivo by TBT and DBT in the blue mussel Mytilus edulis. Mar. Ecol. Prog. Ser. 236: 163-178.
All three studies have been allocated a Klimisch score of 2, however, they all are non-guideline using a non-standard species and in two studies the end-point examined is non standard. They are therefore considered as supporting information only.
Key value for chemical safety assessment
Additional information
No key value has been determined for the chemical safety assessment because all three studies are provided as supporting information only.
In accordance with column 2 of REACH Annex IX, the long-term testing on invertebrate study does not need to be conducted as the chemical safety assessment concludes that the substance is of no immediate concern to the environment. The available data are adequate for classification and labeling purposes and PBT assessment, so no further testing is required.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
