Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 236-813-4 | CAS number: 13494-80-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to reproduction: other studies
Administrative data
- Endpoint:
- toxicity to reproduction: other studies
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Tellurium-induced neuropathy: a model for reversible reductions in myelin protein gene expression
- Author:
- Toews A.D., Lee S.Y., Popko B. and Morell P.
- Year:
- 1 990
- Bibliographic source:
- Journal of Neuroscience Research 26:501-507.
Materials and methods
- Principles of method if other than guideline:
- - Principle of test:
rat model to study temporaly demyeinisation of periferial nerves, followed by a period of rapid remyelinisation.
- Short description of test conditions: pre-pubertal rats are fed for 7 days Te-supplemented chow, and followed up for 30 days.
- Parameters analysed / observed: RNA isolation and analysis for myelin-specific proteins (Po and MBP) - GLP compliance:
- no
- Type of method:
- in vivo
Test material
- Specific details on test material used for the study:
- elemental tellurium powder (60 mesh, Alfa Products, Davers , MA, USA)
Test animals
- Species:
- rat
- Strain:
- Long-Evans
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- Animals were weaned at day 17 and exposed to tellurium from day 20-27 (7 days)
The animals were kept in rooms at constant temeperature of 21+/-2°C, with relative humidity of 50+/-10%, with a 12h light /dark cycle.
Administration / exposure
- Route of administration:
- oral: feed
- Details on exposure:
- Purina milled rodent chaw was mixed with 1.1% Tellurium by weight containing some corn oil to prevent separation.
The supplemented chaw was availbable ad libitum from Day 20 fro 7 days., - Duration of treatment / exposure:
- 7 days
- Frequency of treatment:
- continous availibility ad libitum.
- Duration of test:
- 30 days + first 7 days exposure.
- No. of animals per sex per dose:
- 4-9 animals / for each evaluation point ( = day 1, 3, 5, 9, 15 and 30)
- Control animals:
- yes, concurrent vehicle
- Details on study design:
- Animals were exposed for 7 days and tissue as retreived for analysis on day 1, 3, 5, 9, 15 and 30.
Three separate groups of samples, each derived from separate groups of 7-8 litters, were analyzed.
At each time point, sciatic nerves (that portion distal to the L5 dorsal root ganglion and proximal to the popliteal fossa) were excised and the epineurial/perineurial sheath was removed and discarded; the remaining endoneurial tissue was immediatelyfrozen.
For analysis nerves from 4-9 rats were pooled.
Results and discussion
Observed effects
Most of the increase in total RNA could be accounted for by ribosomal RNA,
Any other information on results incl. tables
Although tellurium blocks cholesterol synthesis in all tissues, including brain, demyelination occurs only in the PNS. Levels of mRNA for MBP did not decrease in brain stem (there was actually a slight increase) as a consequence of exposure to tellurium, indicating that the decreased message levels for myelin proteins seen in sciatic nerve are not the direct result of inhibition of cholesterol synthesis or accumulation of squalene.
Applicant's summary and conclusion
- Conclusions:
- From this paper only the relevant information and results, that could have an impact on the reproductive function are included in this summary.
This study does give any evidence that tellurium might impair the reproductive toxicity function. - Executive summary:
The authours suggest that the sequence of metabolic events in sciatic nerve following tellurium treatment initially involves inhibition of the conversion of squalene to 2,3-epoxysqualene, and that this block in the cholesterol biosynthesis pathway results, either directly or indirectly, in the inhibition of the synthesis of myelin components and breakdown of myelin
But although cholesterol is a precursor for steroid production in the gonads, denovo synthesis is not the rate limiting step in steroidogenesis as cholesterol can be obtained from other sources.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.