Registration Dossier
Registration Dossier
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EC number: 203-401-0 | CAS number: 106-47-8
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Original reported not available, according to BUA report 153
Data source
Referenceopen allclose all
- Reference Type:
- review article or handbook
- Title:
- p-chloroaniline, BUA-Stoffbericht 153
- Author:
- BUA
- Year:
- 1 995
- Bibliographic source:
- Beratergremium für umweltrelevante Altstoffe (BUA) der Gesellschaft Deutscher Chemiker, 1995
- Reference Type:
- secondary source
- Title:
- Benzenamine, 4-chloro, subacute inhalation toxicity study of p-chloroaniline in rats
- Author:
- Du Pont
- Year:
- 1 981
- Bibliographic source:
- unpublish report, Haskell No. 14050
- Reference Type:
- publication
- Title:
- 4-CHLOROANILINE
- Author:
- IPCS-INCHEM
- Bibliographic source:
- in: Concise International Chemical Assessment Document 48
Materials and methods
- Principles of method if other than guideline:
- Acute inhalative study (4 hour inhalation, head-only exposure)
- GLP compliance:
- no
Test material
- Reference substance name:
- 4-chloroaniline
- EC Number:
- 203-401-0
- EC Name:
- 4-chloroaniline
- Cas Number:
- 106-47-8
- Molecular formula:
- C6H6ClN
- IUPAC Name:
- 4-chloroaniline
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Crl: CD rat
- Sex:
- male
Administration / exposure
- Route of administration:
- other: inhalation (vapour/aerosol mixture, respirable fraction 57-95%)
- Type of inhalation exposure:
- head only
- Duration of exposure:
- 4 h
- Concentrations:
- 1690, 1810, 1920, 2101, 2380, 2660 mg/m3
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LC50
- Effect level:
- 2 340 mg/m³ air
- 95% CL:
- 2 200
- Exp. duration:
- 4 h
- Clinical signs:
- other: At all concentrations: cyanosis and lethargy for up to 24 h, clouding of the cornea for up to 14 days
- Body weight:
- Weight loss 7-23%
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
