Registration Dossier

Administrative data

Endpoint:
hydrolysis
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2007
Report Date:
2007

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: EEC Directive 92/69/EEC, Method C.7, OECD Guidelines for the Testing of Chemicals, Method 111.
GLP compliance:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent

Results and discussion

Dissipation DT50 of parent compoundopen allclose all
pH:
4
Temp.:
20 °C
Hydrolysis rate constant:
0 s-1
DT50:
> 8 760 h
Remarks on result:
other: Temp.: CA 20 °C
pH:
7
Temp.:
20 °C
Hydrolysis rate constant:
0 s-1
DT50:
> 8 760 h
Remarks on result:
other: Temp.: CA 20 °C
pH:
9
Temp.:
20 °C
Hydrolysis rate constant:
0 s-1
DT50:
> 8 760 h
Remarks on result:
other: Temp.: CA 20 °C

Applicant's summary and conclusion

Executive summary:

A study was performed to determine the rate of hydrolysis of Trimofix O as a function of pH. The study was performed in accordance with the preliminary test as described in the Annex to EEC Directive 92/69/EEC, Method C.7, and the OECD Guidelines for the Testing of Chemicals, Method 111. The preliminary study showed that at pH 4, 7 and 9 and 50 ± 0.5ºC, less than 10% hydrolysis had occurred after 120 hours (5 days), equivalent to a half-life of greater than 1 year under environmental conditions (25°C). Trimofix O was determined to be hydrolytically stable under acidic, neutral and basic conditions.