Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 500-094-8 | CAS number: 37208-53-0 1 - 6.5 moles propoxylated
Carcinogenicity
Administrative data
Description of key information
Key value for chemical safety assessment
Justification for classification or non-classification
Although no carcinogenicity study is available, it is concluded that carcinogenicity is not an endpoint of concern. There is no evidence from the in vitro genotoxicity studies that 2,2',2''-Nitrilotriethanol, propoxylated is able to induce mutagenicity. Furthermore the available repeated dose toxicity study gives no evidence of serious or severe toxicity up to and including 1000 mg/kg (NOEAL= 1000 mg/kg) and no preneoplastic lesions were observed. Using the weight of evidence, it is concluded that carcinogenicity is not an endpoint of concern for 2,2',2''-Nitrilotriethanol, propoxylated and there is no trigger for a carcinogenicity study.
Additional information
No carcinogenicity study is available but there is information from a qualitative and quantitative understanding of the toxicological properties of the substance that a weight of evidence approach was used to decide on classification.
Proposals concerning long term repeated dose/carcinogenicity studies are set out in Illing and Barratt, (2009). Results can be 'read across', as permitted by Annex XI para 1.5, based on the justification in the reports from Paul Illing Consultancy Services Ltd and Marlin Consultancy (2007 and 2009) and on ECHA guidance. The anticipated result is that the substance is not carcinogenic. Thus, on animal welfare grounds this test should not be undertaken on 2,2',2''-nitrilotriethanol, propoxylated. For further details concerning the justification, consult Illing and Barratt, 2007 and 2009.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
