Registration Dossier
Registration Dossier
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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 213-911-5 | CAS number: 1066-33-7
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable publication which meets basic scientific principles; data taken from EU risk assessment/SIDS
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Studies on the hazard involved in the use of 14C. Retention of carbon from labeled sodium bicarbonate
- Author:
- Skipper HE, White L and Bryan CE
- Year:
- 1 949
- Bibliographic source:
- J. Biol. Chem. 180, 1187-1195
- Reference Type:
- publication
- Title:
- SIDS Initial Assessment Report For SIAM 22
- Author:
- OECD
- Year:
- 2 006
- Bibliographic source:
- OECD SIDS AMMONIUM BICARBONATE
- Reference Type:
- secondary source
- Title:
- Final Report on the Safety Assessment of Sodium Sesquicarbonate, Sodium Bicarbonate, and Sodium Carbonate
- Author:
- Johnson W and Swanson K
- Year:
- 1 987
- Bibliographic source:
- Journal of the American College of Toxicology, 6(1), 121-138
- Reference Type:
- publication
- Title:
- Sodium bicarbonate
- Author:
- US Food and Drug Administration (FDA)
- Year:
- 1 978
- Bibliographic source:
- Federal Register, vol. 43, no. 114, p52440-52443
Materials and methods
- Objective of study:
- excretion
Test guideline
- Qualifier:
- no guideline available
- GLP compliance:
- no
Test material
- Reference substance name:
- Sodium hydrogencarbonate
- EC Number:
- 205-633-8
- EC Name:
- Sodium hydrogencarbonate
- Cas Number:
- 144-55-8
- IUPAC Name:
- sodium hydrogen carbonate
Constituent 1
- Radiolabelling:
- yes
- Remarks:
- 14C-sodium bicarbonate
Test animals
- Species:
- mouse
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- not specified
- Duration and frequency of treatment / exposure:
- single application
Doses / concentrations
- Remarks:
- Doses / Concentrations:
18 µCi
- No. of animals per sex per dose / concentration:
- no data
- Control animals:
- not specified
- Details on dosing and sampling:
- PHARMACOKINETIC STUDY
- Tissues and body fluids sampled: blood and various organs of the body
- Time and frequency of sampling: after 24 and 48h and 1, 2, 4 and 12 weeks
Results and discussion
Toxicokinetic / pharmacokinetic studies
- Details on excretion:
- After 1 h, more than 90 % of the total radioactivity injected was lost through the lungs.
Most of the radioactivity in the blood was in non-carbonate form after 24 h.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
