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EC number: 220-941-2 | CAS number: 2943-75-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 01.08.1991 to 10.10.1991
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 992
- Report date:
- 1992
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: TSCA
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Triethoxyoctylsilane
- EC Number:
- 220-941-2
- EC Name:
- Triethoxyoctylsilane
- Cas Number:
- 2943-75-1
- Molecular formula:
- C14H32O3Si
- IUPAC Name:
- triethoxy(octyl)silane
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Hazleton research Products, Inc., Denver, PA.
- Age at study initiation: 12 to 18 weeks
- Weight at study initiation: 2.1 to 3.2 kg
- Fasting period before study: No
- Housing: Individually in cages with wire floors
- Diet: Ad libitum
- Water: Ad libitum
- Acclimation period: At least five days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 18.9-22.2
- Humidity (%): 33-60%
- Air changes (per hr): No data
- Photoperiod (hrs dark / hrs light): 12/12
IN-LIFE DATES: From: 01.08.1991 to 10.10.1991
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: Dorsal trunk
- % coverage: Not stated - "as large an area as possible" was treated.
- Type of wrap if used: A double layer of gauze sheeting was wrapped around the trunk and secured with adhesive tape. Polyethylene sheeting was then wrapped around the trunk over the gauze. The sheeting was protected with bandaging tape.
REMOVAL OF TEST SUBSTANCE
- Washing (if done): No
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): volume varied according to the weight of the rabbits. - Duration of exposure:
- 24 hours
- Doses:
- 2, 4 and 8 g/kg bw
- No. of animals per sex per dose:
- Five
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Animals were observed frequently for signs of toxicity on the first day of the test, and twice daily thereafter. Weights were recorded on the day of dosing and at 7 and 14 days after dosing and death.
- Necropsy of survivors performed: yes, after 14 days, all survivors were sacrificed. Microscopic examinations were performed on selected tissues from several rabbits. - Statistics:
- The LD50 was calculated by the Moving Average Method.
Results and discussion
Effect levelsopen allclose all
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 6 730 mg/kg bw
- Based on:
- test mat.
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 8 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- One of the female rabbits died following a dose of 8 g/kg bw, but there were no deaths following 4 and 2 g/kg bw. Three, one and no male animals died at 8, 4 and 2 g/kg bw. Deaths occurred on days three to six.
- Clinical signs:
- other: Dermal reactions included erythema, oedema, necrosis, fissuring, desquamation and alopecia (signs of skin irritation at all doses in both sexes). Signs of toxicity included sluggishness, an unsteady gait, laboured breathing, forelimb paralysis (one male t
- Gross pathology:
- Necropsy of the animals that died revealed hemorrhaged intestines (one animal) and a small amount of blood in the urine of one. In survivors there were instances of dark/bright red lungs, intestines of one animal were partially filled with gas, an enlarged spleen and a raised tan nodule on one kidney.
- Other findings:
- Selected tissues from six males and six females were examined microscopically. Lesions observed included interstitial nephritis and calculi in the urinary bladder. These findings were considered to be incidental and not related to the treatment. There were no lesions apparent in the examined spinal cords or sciatic nerves of any animal.
Any other information on results incl. tables
Table 1 Summary of acute dermal study results
Dose (g/kg bw) | Dead/dosed | Mean weight (g ± SD) | Signs of toxicity | ||
0 days | 7 days | 14 days | |||
8.0 (males) | 3/5 | 2364 ± 116 | 2228 ± 97 | 2448 ± 86 | Sluggishness in 1 at day 1, emaciation of 1 at death. Weight loss evident in survivors at 7 days with recovery by 14 days. |
4.0 (males) | 1/5 | 2534± 153 | 2360 ± 89 | 2496 ± 164 | Sluggishness in 1, unsteady gait in 2 at day 1; laboured breathing and forelimb paralysis in 1 that died at 1 day; hindlimb paresis in 3 at 2 days, emaciation of 1 at death. Partial recovery of 2 from paresis at day 7. Complete recovery of 3 at 2 to 14 days. |
2.0 (males) | 0/5 | 2604± 202 | 2444± 166 | 2651± 160 | Iritis in 1 at day 1. Recovery at 2 days. Emaciation of 1 at 6 days, paresis (weakness) in all limbs of 1 at 7 days. Complete recovery at 14 days. |
8.0 (females) | 1/5 | 2778± 63 | 2368± 254 | 2551± 277 | Sluggishness in 2, unsteady gait in 1, laboured breathing in 1, slight wetness of perinasal fur of 1 at day 1; paresis (difficulty in standing) in 2 survivors at 1 or 7 days; emaciation of 3 at death or 7 days. Death of 1 at 4 days. All survivors recovered at 7 to 14 days. |
4.0 (females) | 0/5 | 2415± 151 | 2342± 180 | 2533± 192 | Sluggishness and slight swaying motion of head in 1 at day 1. Recovery at 14 days. |
2.0 (females) | 0/5 | 2277± 85 | 2323± 69 | 2575± 110 | None noted. |
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- In an acute dermal toxicity study conducted using a protocol comparable to OECD 402, and in compliance with GLP (reliability score 1) the LD50 for male rabbits was 6730 mg/kg bw, and for females was at least 8000 mg/kg bw. Dermal reactions included erythema, oedema, necrosis, fissuring, desquamation and alopecia (signs of skin irritation at all doses in both sexes). Signs of toxicity included sluggishness, an unsteady gait, laboured breathing, forelimb paralysis (one male that died), hindlimb paresis (reversible weakness to temporary loss of ability to stand), nephrititis, slight wetness of the perinasal fur, head with swaying motion. Recovery of survivors was 2-14 days. There were no treatment-related microscopic findings.
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