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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Toxicity to microorganisms

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Administrative data

Link to relevant study record(s)

Reference
Endpoint:
toxicity to microorganisms, other
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Remarks:
Experimental data of test chemical
Justification for type of information:
Experimental data of test chemical from collection of data
Reason / purpose for cross-reference:
read-across source
Reason / purpose for cross-reference:
read-across source
Qualifier:
according to guideline
Guideline:
other: as mentioned below
Principles of method if other than guideline:
WoE report is based on two toxicity study of microorganisms for the test chemical :
1 and 2 . Cell multiplication inhibition test was carried out to study the effects of test material on microorganism.
GLP compliance:
no
Analytical monitoring:
no
Vehicle:
no
Test organisms (species):
Pseudomonas putida
Details on inoculum:
No data available
Test type:
static
Water media type:
freshwater
Limit test:
no
Details on test conditions:
No data available
Reference substance (positive control):
not specified
Dose descriptor:
other: TT
Effect conc.:
220 mg/L
Nominal / measured:
not specified
Conc. based on:
test mat.
Basis for effect:
growth inhibition
Remarks on result:
other: Read across 1
Dose descriptor:
other: TT
Effect conc.:
62 mg/L
Nominal / measured:
not specified
Conc. based on:
test mat.
Basis for effect:
growth inhibition
Remarks on result:
other: Read across 2
Validity criteria fulfilled:
not specified
Conclusions:
The test chemical is likely to be toxic to microorganism in the dose range of 62-220 mg/l .
Executive summary:

Data available for the test chemicals has been reviewed to determine the toxicity of microorganism of the test chemical.The studiesare as mentioned below:

In the first study Cell multiplication inhibition test was carried out to study the effects of test material on Pseudomonas putida. The threshold toxcity of test material on cell multiplication inhibition effect on Pseudomonas putida was observed to be 220 mg/L.

Similarly cell multiplication inhibition test was carried out to study the effects of test material on Pseudomonas putida. The threshold toxcity of test material on cell multiplication inhibition effect on Pseudomonas putida was observed to be 62 mg/L.

Description of key information

The test chemical  is  likely to be toxic to microorganism  in the dose range of  62-220 mg/l .

Key value for chemical safety assessment

EC50 for microorganisms:
62 mg/L

Additional information

Data available for the test chemical and read across chemical selected on the basis of structual similarity has been reviewed to determine the toxicity of microorganism of the test chemical.The studiesare as mentioned below:

In the first study Cell multiplication inhibition test was carried out to study the effects of test material on Pseudomonas putida. The threshold toxcity of test material on cell multiplication inhibition effect on Pseudomonas putida was observed to be 220 mg/L.

Similarly cell multiplication inhibition test was carried out to study the effects of test material on Pseudomonas putida. The threshold toxcity of test material on cell multiplication inhibition effect on Pseudomonas putida was observed to be 62 mg/L.