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Diss Factsheets
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EC number: 203-347-8 | CAS number: 105-95-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
Weight of Evidence approach; geometric mean between the two results (experimental and QSAR results):
- 48h-EC50 = 4.65 mg/L.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 4.65 mg/L
Additional information
Due to the unexpected and inconsistent loss of substance observed in the static experimental study (EU Method C.2 with GLP statement), a weight of evidence approach with ECOSAR estimation has been used to assess the acute toxicity of the substance to aquatic invertebrates.
In the acute toxicity study, performed according to EU Method C.2 with GLP statement, Daphnia magna were exposed to the substance at nominal concentrations of 0 (blank control), 3.2, 5.0, 6.4, 10.0, 12.8 and 20.0 mg/L under static conditions. Analytical monitoring of the concentrations was performed at t = 0h and t= 48h. This study is considered invalid because the test method used was not appropriate, the substance was apparently lost rapidly during this static test although similar final concentrations of the test substance were found in all test solutions at the end of the study. This profile would not be expected for a relatively low volatility substance tested below the water solubility limit as is the case here. The EC50 value was therefore recalculated with ToxRat Professional v2.10 using the initial measured concentrations. The recalculated 48h-EC50 for Daphnia magna was determined to be 8.09 mg/L (95% CL: 7.39 - 8.87 mg/L).
In addition, the short term toxicity of the substance to daphnid was estimated using the ECOSAR v1.11 QSAR model available from the U.S. EPA.
The estimation 48h-LC50 was 2.67 mg/L (esters class), calculated from a measured log Kow value (4.3) and a linear regression. The substance falls within the applicability domain and therefore the predicted value can be considered reliable.
To obtain a more reliable EC50 value, the geometric mean between these two results was determined to be 4.65 mg/L.
Further investigation is ongoing on this difficult substance in order to determine whether instability or analytical issues account for the rapid loss observed under ecotoxicological test conditions.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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