Registration Dossier

Physical & Chemical properties

Partition coefficient

Currently viewing:

Administrative data

Link to relevant study record(s)

Reference
Endpoint:
partition coefficient
Type of information:
calculation (if not (Q)SAR)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
accepted calculation method
Reason / purpose:
reference to same study
Reason / purpose:
reference to same study
Qualifier:
no guideline required
Principles of method if other than guideline:
calculation method. documentation see attached study report
GLP compliance:
no
Other quality assurance:
ISO/IEC 17025 (General requirements for the competence of testing and calibration laboratories)
Type of method:
estimation method (solubility ratio)
Partition coefficient type:
octanol-water
Analytical method:
other: not rrquired, calculation
Key result
Type:
Pow
Partition coefficient:
0
Temp.:
20 °C
pH:
> 3 - < 9
Key result
Type:
log Pow
Partition coefficient:
1
Temp.:
20 °C
pH:
3 - < 9
Conclusions:
the partition coefficient of momobutyltin trichloride was calculated to be log Pow = 1, based on solobility in water and n-octanol

Description of key information

It was not possible to perform the test due to the low water solubility of the material and technical difficulties arising in the analysis of the material. Furthermore it is not possible to calculate a value as there are no validated QSAR methods for organometallics. The key value used was the Mean Kow determined from the bioaccumulation study, Tsuda et al (1988)

Key value for chemical safety assessment

Log Kow (Log Pow):
1.145

Additional information

Until very recently, the substance was considered to exhibit properties such that a waiver has been submitted to address this end point based on data to suggest the substance rapidly hydrolysed. This is no longer believed to be the case and new information now indicates the substance may in fact behave differently than originally thought. A new partition coefficient study is therefore to be attempted to try and obtain a definitive result. The study is expected to be finished second quarter 2019 and the registration is proposed to be updated to take account of this information in late secoond quarter/ third quarter 2019.