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EC number: 214-263-6 | CAS number: 1118-46-3
No specific neurotoxicity studies have been performed however, neurological endpoints (i.e. arena testing, FOBs and motor activity assessment), as well as brain weight and microscopic examination of the brain and a peripheral nerve (sciatic) were all included in a fully compliant 90-day toxicity study in rats. None of these parameters were affected following treatment for 13 consecutive weeks at dosages up to and including 7500 ppm (521 mg/kg bw/day in males, and 533 mg/kg bw/day in females). In addition, no effects on brain weight and no microscopic abnormalities were observed in a 28-day inhalation study even at the highest tested concentration of 21.53 mg/m3, which was lethal to some animals.
The registered substance is not considered to possess any neurotoxic potential.
A fully compliant subchronic 90-day dietary toxicity study, up to 7500 ppm, did not reveal any treatment-related effects at FOBs and motor activity assessments, and no changes in brain weight or histopathology. No effects on brain weight and histopathology were noted in a 28-day inhalation study, including a lethal concentration. The test material is not considered to possess any neurotoxic potential.
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