Registration Dossier
Registration Dossier
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EC number: 619-079-3 | CAS number: 949109-75-5
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 15 days
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The study was conducted according to a study protocol comparable to current guideline and in compliance with GLP. However, a limitation of the study was the lack of information on the purity of the test material.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 982
- Report date:
- 1982
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EPA OPPTS 870.1100 (Acute Oral Toxicity)
- Principles of method if other than guideline:
- 5 Male and 5 female SD rats were fasted overnight prior to receiving a single oral dose of 5.0 g/kg (bw) of the test article . They were then observed frequently on the day of dosing and daily for a total of 15 days. All gross and visible toxic or pharmacological effects were recorded.
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Not applicable-UVCB
- EC Number:
- 619-079-3
- Cas Number:
- 949109-75-5
- Molecular formula:
- UVCB- Mixture of many formulae.
- IUPAC Name:
- Not applicable-UVCB
- Test material form:
- other: 25g test material added to 50 ml corn oil
- Details on test material:
- Test article ID - 82-0272
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Doses:
- Single oral dose of 5 g/kg (bw) - 25 g of test substance in 50 ml of corn oil as vehicle. Prepared physical state was described in the report as a "slurry".
- No. of animals per sex per dose:
- 5 male and 5 female per dose.
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
- Remarks:
- Migrated information
- Conclusions:
- In a well conducted LD50 oral study in rats, 5 g/kg (bw) was adminstered by gavage to a group of 5 male and 5 female SD rats and observed for a period of 15 days for signs of lethality and other overt effects. During the study there were no treatment related effects and the LD50 > 5 g/kg (bw).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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