Registration Dossier
Registration Dossier
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EC number: 287-824-6 | CAS number: 85586-21-6
Toxicity to soil macroorganisms except arthropods
Administrative data
Link to relevant study record(s)
Description of key information
NOEC (28 d and 56 d) ≥ 1000 mg/kg dw for Eisenia fetida (OECD 222)
Key value for chemical safety assessment
Additional information
No experimental data evaluating the toxicity of Fatty acids, C16-18, methyl esters (CAS No. 85586-21-6) to soil macroorganisms are available. Therefore, data from a structurally related category member (methyl palmitate (CAS No. 112-39-0) are used as read-across in accordance with Regulation (EC) No. 1907/2006, Annex XI, 1.5. Both substances are fatty acids esterified with methanol, containing fatty acid C-chain ranges of C16 (CAS No. 112-39-0) and C16-18 (CAS No. 85586-21-6) respectively. The log Pow values (> 5) reported for both substances indicate a high adsorption potential to soil particles. Based on the above information, it is justified to use the toxicity data from methyl palmitate as read-across for Fatty acids, C16-C18, methyl esters.
One study evaluating the chronic toxicity of methyl palmitate (CAS No. 112-39-0) to earthworms is available (Winkelmann, 2013). This test was conducted according to OECD 222, under GLP conditions. Eisenia fetida was exposed to the test substance for 56 days at a concentration of 1000 mg/kg dw (limit test). Mortality and growth were evaluated after 28 days whereas reproduction was evaluated after 56 days. After the exposure period, no effects on earthworm’s survival, reproduction or growth were observed, leading to a NOEC ≥ 1000 mg/kg dw.
Based on the results obtained for the structurally related category member (in accordance with Regulation (EC) No. 1907/2006, Annex XI, 1.5), it can be concluded that Fatty acids, C16-18, methyl esters will not exhibit toxicity to soil macroorganisms.
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