2-hydroxyethyl acrylate

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1980

Report date:

1980

Materials and methods

Principles of method if other than guideline:

Groups of 5 male Sherman rats were administered doses of 126, 252, 500, 1000, and 2000 mg/kg bw by gavage. The animals were observed for lethality, changes in general appearance and demeanor and body weight gain during a 14-day post-exposure period.

GLP compliance:

no

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

2-hydroxyethyl acrylate

EC Number:

212-454-9

EC Name:

2-hydroxyethyl acrylate

Cas Number:

818-61-1

Molecular formula:

C5H8O3

IUPAC Name:

2-hydroxyethyl acrylate

Test material form:

not specified

Details on test material:

not specified

Test animals

Species:

rat

Strain:

Sherman

Sex:

male

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Fasting period before study: yes

ENVIRONMENTAL CONDITIONS
no details

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

corn oil

Details on oral exposure:

VEHICLE
- Concentration in vehicle: 10 %

Doses:

126, 252, 500, 1000, and 2000 mg/kg bw

No. of animals per sex per dose:

5

Control animals:

not specified

Details on study design:

- Duration of observation period following administration: 14 days
- Necropsy of survivors performed: no data
- Other examinations performed: clinical signs, body weight

Statistics:

Weil CS (1952). Biometrics 8: 249-263

Results and discussion

Effect levels

Key result

Sex:

male

Dose descriptor:

LD50

Effect level:

540 mg/kg bw

95% CL:

>= 390 - <= 750

Mortality:

At the highest dose of 2000 mg/kg bw 5/5 rats died within 2-24 hrs after dosing. At the doses of 1000 and 500 mg/kg bw 2/5 rats died within 24 hrs after administration. At the two lower doses of 252 and 126 mg/kg bw, no mortality occurred.

Clinical signs:

other: No changes in general appearance and demeanor were observed among any of the surviving animals.

Applicant's summary and conclusion

Interpretation of results:

Category 4 based on GHS criteria