Hexamethylene diisocyanate

Repeated dose toxicity: oral

Administrative data

Endpoint:

short-term repeated dose toxicity: oral

Type of information:

experimental study

Adequacy of study:

other information

Reliability:

3 (not reliable)

Rationale for reliability incl. deficiencies:

other: does not meet important criteria of today standard methods; poor documentation

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1961

Report date:

1961

Materials and methods

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

Oral gavage study with 6 male rats over 2 weeks.

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

Hexamethylene diisocyanate

EC Number:

212-485-8

EC Name:

Hexamethylene diisocyanate

Cas Number:

822-06-0

Molecular formula:

C8H12N2O2

IUPAC Name:

1,6-diisocyanatohexane

Test animals

Species:

rat

Strain:

other: albino ChR-CD

Sex:

male

Details on test animals or test system and environmental conditions:

no data

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

peanut oil

Details on oral exposure:

no data

Analytical verification of doses or concentrations:

not specified

Duration of treatment / exposure:

10 administrations over a 2-week period

Frequency of treatment:

daily

Doses / concentrations

Remarks:

Doses / Concentrations:
300 mg/kg
Basis:
actual ingested

No. of animals per sex per dose:

6

Control animals:

no

Details on study design:

3 rats were chosen at random for sacrifice 4 hours after the tenth treatment and 3 rats were kept for a 10-day observation period

Results and discussion

Effect levels

1

Dose descriptor:

NOAEL

Sex:

male

Remarks on result:

not determinable

Remarks:

no NOAEL identified

2

Dose descriptor:

LOEL

Effect level:

300 mg/kg bw/day (actual dose received)

Sex:

male

Target system / organ toxicity

Critical effects observed:

not specified

Any other information on results incl. tables

HDI as a five per cent solution in peanut oil was administered by stomach tube daily for ten days over a two-week period at a dose level of 300 ma/kg to six male albino ChR-CD rats. Although the rats showed diarrhea and salivation, and appeared uncomfortable after most treatments, they survived. During the first week, weight losses were observed consistently in all animals. During the second week, there were sporadic weight losses, but most animals gained weight. High water eonsumption was also noted in the treated rats during the second week. No clinical signs of toxicity were observed during the 10-days recovery period. Gross and microscopic examination of tissues revealed an ulcerative gastritis in rats sacrificed the tenth treatment day, and healing gastritis in rats sacrificed ten days later.