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EC number: 215-213-6 | CAS number: 1313-96-8
Total number of animals examined:
No mortality was observed in any male from various treatment and control group during the entire period of the study.
One female animal from low dose was found dead on gestation day 15 due to gavaging error (not attributed to test item).
Clinical Observations – Male
Total number of animals examined
No clinical signs were observed in any male from various treatment and control group during the entire period of the study.
Clinical Observations – Female
No clinical signs were observed in any female from various treatment and control group during the entire period of the study.
Copulation Index (%)= (No. of rats copulated /No.of pairs)X 100
Fertility Index (%)= (No. of Females Pregant/No.of females copulated)x 100
Delivery Index(%)= (No. of dams with live newborns/ No.of pregnant dams)X 100
Viability Index (%)= (No. of live offspring at day 4/ No.of live offspring at birth)x 100
No. of live offspring at day 4/ No.of live offspring at birth)x 100
Macroscopic Findings - Male
Left seminal vesicle diminished
Epididymidis-yellowish, whitish deposition (bilateral)
Right epididymis-yellowish, whitish deposition
Lung redish discolouration
Left Epididymidis-yellowish, whitish deposition
Right seminal vesicle with white spots( 1-2mm)
Macroscopic Findings- Female
Lymph nodes axillary: left slightly enlarged; right red discolouration at the margin
Lung-residuals of the test item
Kidney- small cyst on right kidney.
Thymus- slightly reduced in size
Lung-slight bloody, red spots
oesophagos-residuals of the test item
Axillary lymphnode-left slightly enlarged
Lung- bloody, red discoloured
Tabular Study Summary
Pairs started (N)
Females showing evidence of copulation (N)
Females achieving pregnancy (N)
Conceiving days 1 - 5 (N)
Conceiving days 6 - . . .(1) (N)
Pregnancy = 21 days or below (N)
Pregnancy = 22 days (N)
Pregnancy ³ 23 days (N)
Dams with live young born (N)
Dams with live young at day 4 pp (N)
Corpora lutea/dam (mean)
Live pups/dam at birth (mean)
Live pups/dam at day 4 (mean)
Sex ratio (m/f) at birth (mean)
Sex ratio (m/f) at day 4 (mean)
Litter weight at birth (mean)
Litter weight at day 4 (mean)
Pup weight at birth (mean)
Pup weight at day 4 (mean)
Dams with 0
Dams with 1
Dams with 2
LOSS OF OFFSPRING
Pre-implantation (corpora lutea minus implantations)
Females with 0
Females with 1
Females with 2
Females with 3 and more
Pre-natal (implantations minus live births)
Females with 3
Post-natal (live births minus alive at post natal day 4)
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