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Diss Factsheets

Physical & Chemical properties

Solubility in organic solvents / fat solubility

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Administrative data

Endpoint:
solubility in organic solvents / fat solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2001-2013
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Work was not performed under GLPs.

Data source

Referenceopen allclose all

Reference Type:
other company data
Title:
Unnamed
Year:
2001
Reference Type:
study report
Title:
Unnamed
Year:
2013
Reference Type:
publication
Title:
In vitro and in ovo effects of four bromianted flame retardants on toxicity and hepatic mRNA expression in chicken embryos
Author:
Egloff et al
Year:
2011
Bibliographic source:
Toxicology Letters 201:25-33, page 26
Reference Type:
study report
Title:
Unnamed
Year:
2008
Reference Type:
study report
Title:
Unnamed
Year:
2004

Materials and methods

Test guideline
Qualifier:
no guideline required
Principles of method if other than guideline:
Standard laboratory methods for determination of solubility were used in the various studies.
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
1,1'-(ethane-1,2-diyl)bis[pentabromobenzene]
EC Number:
284-366-9
EC Name:
1,1'-(ethane-1,2-diyl)bis[pentabromobenzene]
Cas Number:
84852-53-9
Molecular formula:
C14H4Br10
IUPAC Name:
1,2,3,4,5-pentabromo-6-[2-(2,3,4,5,6-pentabromophenyl)ethyl]benzene
Test material form:
other: commercial DBDPEthane product or analytical standard supplied in toluene
Details on test material:
Test material commercial DBDPEthane product: Albemarle 2001, Featherstone and Landry 2013, Griffin 2008, Sims 2004
Test material analytical standard supplied in toluene: Egloff et al. 2011

Results and discussion

Solubility in organic solvents / fat solubilityopen allclose all
Medium:
acetone
Solubility:
< 0.01 other: weight %
Temp.:
25 °C
Remarks on result:
other: Albemarle 2001
Medium:
methanol
Solubility:
< 0.01 other: weight %
Temp.:
25 °C
Remarks on result:
other: Albemarle 2001
Medium:
toluene
Solubility:
< 0.01 other: weight %
Temp.:
25 °C
Remarks on result:
other: Albemarle 2001
Medium:
other: chlorobenzene
Solubility:
< 0.01 other: weight %
Temp.:
25 °C
Remarks on result:
other: Albemarle 2001
Medium:
other: methylene dibromide
Solubility:
< 0.01 other: weight %
Temp.:
25 °C
Remarks on result:
other: Albemarle 2001
Medium:
other: dimethylformamid
Solubility:
< 0.01 other: weight %
Temp.:
25 °C
Remarks on result:
other: Albemarle 2001
Medium:
n-octanol
Solubility:
850 µg/L
Temp.:
23 °C
Remarks on result:
other: Featherstone and Landry 2013
Medium:
DMSO
Solubility:
0.02 mg/L
Remarks on result:
other: Egloff et al. 2011; GCMS(ECNI); suspension allowed to settle & measured in supernate; test material was analytical standard supplied in toluene
Medium:
DMSO
Solubility:
> 0.325 - <= 0.625 other: microM
Remarks on result:
other: Cyprotex 2008; LC-UV; ambient temp; test material was commercial DBDPEthane product
Medium:
other: cell culture buffer solution (HHanks Balanced Salt Solution)
Solubility:
< 0.128 other: microM
Remarks on result:
other: Cyprotex 2008; LC-UV; ambient temp; test material was commercial DBDPEthane product
Details on results:
The results are continued in the second record for this endpoint.

Any other information on results incl. tables

Summary Table (records .001 and .002).

SOLVENT

Solubility

Method

Source

Units as Originally Reported

μg//L

Acetone

<0.01 wt%

<10000

GC

ALB 2001

<0.01 mg/mL

<10

HPLC-UV

RTI 2012

Methanol

<0.01 wt%

<10000

GC

ALB 2001

Toluene

<0.01 wt%

<10000

GC

ALB 2001

40 ug/mL

40000

HPLC-UV

RTI 2012

Chlorobenzene

<0.01 wt%

<10000

GC

ALB 2001

Methylene dibromide

<0.01 wt%

<10000

GC

ALB 2001

DMF

<0.01 wt%

<10000

GC

ALB 2001

n-Octanol

0.85 ppm

850

HPLC-UV

ALB 2013

DMSO

0.02 mg/L

20*

GCMSECNI

Egloff 2011

>0.325<0.625 μM

>0.325<0.625

HPLC-UV

Cyprotex 2008

<0.1 mg/mL

<100

HPLC-UV

RTI 2012

Ethanol

<0.01 mg/mL

<10

HPLC-UV

RTI 2012

Chloroform

0.005 mg/mL

<5

HPLC-UV

RTI 2012

*Determined for an analytical standard supplied in toluene.

Applicant's summary and conclusion

Conclusions:
The solubility of DBDPEthane in 10 organic solvents has been assessed in several laboratories using a variety of analytical methods. DBDPEthane shows very limited solubility in all 10 solvents.
Executive summary:

The solubility of DBDPEthane in 10 organic solvents has been assessed in several laboratories using a variety of analytical methods. DBDPEthane shows very limited solubility in all 10 solvents.