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EC number: 229-146-5 | CAS number: 6419-19-8
TEST SUBSTANCE GROUP RESPONSES
One animal died immediately after the intracutaneous application, with bleeding from the nose.
No evidence of sensitisation was observed. Necropsy findings included catarrhal enteritis, bulging stomach and cecum (indigestion), pulmonary congestion, enlarged left side of the heart. Clear structure of the liver lobules.
CONTROL GROUP RESPONSES
One animal died during the exposure.
No evidence of sensitisation was observed. After removal of patch one animal had white dots in left eye.
OTHER: The Freund’s adjuvant resulted in necrosis which resulted in scar tissue during the treatment free period of the experiment. After the Patch-test with of 48 hours general redness was seen and the injection sites were blood stained. Crust formation was present at injection sites in both the test and control animals.
In a skin sensitisation study conducted using a protocol which was a variation of the Magnusson and Kligman method (reliability score 2), ATMP (in water) was applied to the skin of 20 Pirbright guinea-pigs, 20 additional guinea-pigs served as negative controls. One animal from the test and control group died, and the study was negative for skin sensitisation (48 and 72 hours after exposure). Further details are available in the study report, but this needs proper translation.
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