Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not sensitising)
Additional information:

Non human data

CAS 68475-80-9 (E000014200): Albino guinea pigs were dermally exposed to neat E000014200 at a volume of 0.5 mL for induction phases one and two and to a 1:2 v/v dilution (in mineral oil) for induction three. The test article was administered as a 1:4 v/v dilution (in mineral oil) for the challenge phase for both the induction/challenge and challenge control group animals. Following challenge there were no responses in E000014200 or vehicle control animals whilst all 10 in the positive control group had responses (UBTL, 1990e).

The components benzene, toluene, ethylbenzene, styrene, naphthalene, biphenyl and anthracene are considered not to be skin sensitisers.

Human data

The only human data identified was for benzene:

Benzene (No classification): In a study using 25 male volunteers a maximisation test with induction using 50% benzene and challenge with 20% benzene no evidence of skin sensitisation was seen (Kligman, 1966).


Migrated from Short description of key information:
Fuel Oils streams are considered not to be skin or respiratory sensitisers. Specific data for one Fuel Oils stream E000014200 (CAS 68475-80-9) indicates that it is not a skin sensitiser. The components benzene, toluene, ethylbenzene, styrene, naphthalene, biphenyl and anthracene are considered not to be skin sensitisers.

Respiratory sensitisation

Endpoint conclusion
Additional information:

No specific animal or human data have been found with regard to respiratory sensitisation for any components within this stream.


Migrated from Short description of key information:
No data have been found concerning respiratory sensitisation and there are no indications that components within this stream are respiratory allergens.

Justification for classification or non-classification

There are sufficient data on E000014200 (CAS 68475-80-9) and on component substances to indicate that Fuel Oils streams are not skin sensitisers. Although there are no specific data on respiratory sensitisation of Fuel Oils streams or marker components there are no indications that components within this stream are respiratory allergens. It is proposed that no classification is warranted for these end-points under Dir 1999/45/EC or Reg (EC) 1272/2008.