Lauric acid

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: Guideline study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1981

Report date:

1981

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

Deviations:

no

GLP compliance:

no

Test type:

standard acute method

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

Lauric acid

EC Number:

205-582-1

EC Name:

Lauric acid

Cas Number:

143-07-7

Molecular formula:

C12H24O2

IUPAC Name:

dodecanoic acid

Details on test material:

- Name of test material (as cited in study report): Edenor C 12 98/100, SIS-Nr 611 (lauric acid 98 - 100 %)
- Physical state: A solid white substance (tallow-like)
- Analytical purity: 98 - 100 %

Test animals

Species:

rat

Strain:

Wistar

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Source: Supplied by Winkelmann, Hannover, Germany
- Weight at study initiation: Mean body weights of male and female rats were 164 and 133 g, respectively
- Fasting period before study: 18 hours prior to dosing (feeding only)
- Housing: Same sex-groups of five Wistar rats were housed in type III Makrolon-cages containing soft wood granulated material
- Diet: A standard laboratory animal diet (Altromin for rats)
- Water: ad libitum



ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22
- Humidity (%): 45 - 60
- Photoperiod (hrs dark / hrs light): 12 / 12

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

water

Details on oral exposure:

VEHICLE
- Concentration in vehicle: 250 mg/mL
- Amount of vehicle (if gavage): 20 mL/kg bw


MAXIMUM DOSE VOLUME APPLIED: 20 mL/kg bw

Doses:

5000 mg/kg bw

No. of animals per sex per dose:

5

Control animals:

not specified

Details on study design:

- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Clinical observations were performed immediately after dosing and 1, 4 and 24 hours after dosing, then once every 24 hours thereafter for the rest of the observation period. Individual bodyweights were measured immediately prior to dosing and 24 hours after dosing as well as 7 and 14 days after dosing.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

> 5 000 mg/kg bw

Based on:

test mat.

Mortality:

No mortality occurred

Clinical signs:

other: Clinical signs appeared approximately 20 minutes after dosing including slightly ruffled fur, which subsided completely within 24 hours. No other effects noted.

Gross pathology:

Slight reddening of the gastric mucosa was noted. No other effects noted.