Registration Dossier
Registration Dossier
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EC number: 310-060-2 | CAS number: 102110-59-8
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
There are no reliable test reports on the skin sensitisation induced by silicates. Silicates have been evaluated as nonsentising by Cosmetic Ingredient Review Expert Panel, which was established by the industry trade association with the support of the U.S. Food and Drug Administration and the Consumer Federation of America. Although funded by the Council, CIR and the review process are independent of the Council and the cosmetics industry.
Several silicates have been approved as food additives. Many silicates are also accepted as excipients in medicines.
No reliable reports on occupational sensitisations have been found.
Migrated from Short description of key information:
No data are available on the sensitising potential of Si/FeSi silicate. Silicates have been in consumer use long and extensively as food additives, as excipients in medicines and as ingredients in cosmetics. For these kind of consumer used no sensitising potentials have been seen. There are no reports for sensitisation in occupational use.
Respiratory sensitisation
Endpoint conclusion
- Additional information:
- Migrated from Short description of key information:
No data is available on respiratory sensitisation.
Justification for classification or non-classification
There are no data indicating a need for silicates to be classified as sensitising, and therefore Si/FeSi silicate is not suggested to be classified for sensitisation.
There are no reliable reports on the skin sensitisation by silicates. They have been evaluated as nonsentising by the Cosmetic Ingredient Review Expert Panel, which was established by the industry trade association with the support of the U. S. Food and Drug Administration and the Consumer Federation of America. Although funded by the Council, CIR and the review process are independent of the Council and the cosmetics industry.
Several silicates have bee approved as food additives and excipients in medicines.
No reliable reports on occupational sensitisations have been found.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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