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Diss Factsheets

Ecotoxicological information

Short-term toxicity to fish

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Administrative data

Link to relevant study record(s)

short-term toxicity to fish
Type of information:
experimental study
Adequacy of study:
key study
Study period:
October 4 to 8, 1993
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
comparable to guideline study with acceptable restrictions
equivalent or similar to guideline
OECD Guideline 203 (Fish, Acute Toxicity Test)
not specified
GLP compliance:
Translated report says "GLP Compatible"
Analytical monitoring:
not specified
Details on sampling:
No details
Details on test solutions:
PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
- Method: direct dissolution in water
Test organisms (species):
Oryzias latipes
Details on test organisms:
Stated in the report as Himedaka, bred in house. Average length 2.1 +/- 1.1 cm (n=20), average weight 0.096 +/- 0.015 g (n=20). The fish were held under fluorescent light with a 16 hours light and 8 hour dark regimen.
Test type:
Water media type:
Limit test:
Total exposure duration:
96 h
Post exposure observation period:
37 (reported as solidity). Alkalinity - 33 (no units stated). Ca:Mg ratio = 2.9, Na:K ratio = 2.3
Test temperature:
23 +/- 0.2 degree C
7.0 - 7.4 in the control, 7.1 to 7.6 in the 100 mg/L treatment over the duration of the exposure period.
Dissolved oxygen:
5.9 to 7.8 mg/L in the control, 6.1 to 7.7 mg/L in the 100 mg/L treatment over the duration of the exposure period.
Not applicable
No details
Nominal and measured concentrations:
100 mg/L
Details on test conditions:
The 100 mg/L test medium was colourless and transparent.
Reference substance (positive control):
Key result
96 h
Dose descriptor:
Effect conc.:
> 100 mg/L
Nominal / measured:
Conc. based on:
test mat.
Basis for effect:
mortality (fish)
Details on results:
There was no mortality in either the control or 100 mg/L treatments over the 96 hour exposure period.
Results with reference substance (positive control):
Not applicable
Reported statistics and error estimates:
Not applicable
Validity criteria fulfilled:
The 96 hour LC50 for Oryzias latipes exposed to a 100 mg/L pentaerythritol medium over a 96 hour period was observed to be greater than 100 mg/L (the highest nominal exposure concentration tested).
Executive summary:

The 96 hour LC50 for Oryzias latipes exposed to pentaerythritol was observed to be >100 mg/L (the highest nominal exposure concentration tested).

Description of key information

An experimental study which investigated the acute toxicity of pentaerythritol to the freshwater/brackish fish species, Oryzias latipes, showed no mortality in 100 mg/L exposure concentrations of the test substance throughout the 96 hour exposure period. The 96 hour LC50 for O. latipes exposed to pentaerythritol was therefore concluded to be >100 mg/L (the highest nominal exposure concentration tested) (Fukuoka, 1993).

Key value for chemical safety assessment

Fresh water fish

Fresh water fish
Effect concentration:
100 mg/L

Additional information