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EC number: 204-104-9 | CAS number: 115-77-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Older proprietary study also published as an abstract, scientifically acceptable.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 963
- Report date:
- 1963
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Principles of method if other than guideline:
- An acute dermal toxicity limit test was conducted in albino rabbits; the study was conducted prior to development of the guidelines, however the methodology are broadly comparable to OECD 402.
- GLP compliance:
- no
- Remarks:
- predates GLP
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Pentaerythritol
- EC Number:
- 204-104-9
- EC Name:
- Pentaerythritol
- Cas Number:
- 115-77-5
- Molecular formula:
- C5H12O4
- IUPAC Name:
- 2,2-bis(hydroxymethyl)propane-1,3-diol
- Details on test material:
- Pentaerythritol (PE 200), received from Hercules Powder Company, Inc.
Constituent 1
- Specific details on test material used for the study:
- Pentaerythritol (PE 200), received from Hercules Powder Company, Inc.
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- The animals were male and female New Zealand White rabbits. The average body weight of the rabbits was approximately 2.5 kg. All rabbits had been maintained under observation in the laboratory for 7 days prior to testing. During the pre-test period, the animals were examined with respect to their general health and suitability as test animals.
The rabbits were housed in individual stainless steel cages and maintained on the standard laboratory rabbit ration. Food and water were available ad libitum.
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- water
- Details on dermal exposure:
- Twenty four hours prior to application, the abdomen of each rabbit was shaved free of hair with electric clippers. The shaved area was approximately 10% of the total body surface.
The rabbits received an application of the test material at a dose of 10 g/kg. The test material was applied as an aqueous paste. The test sites were covered by wrapping the trunk of the rabbit with an imprevious plastic sheeting which was securely taped in place. - Duration of exposure:
- 24 hours
- Doses:
- 10 g/kg
- No. of animals per sex per dose:
- 2 males and 2 females
- Control animals:
- not required
- Details on study design:
- Just prior to application of the test substance, the skin of one male and one female was abraded by making a series of epidermal incisions every 2-3 cm longitudonally over the exposure site. The incisions were sufficiently deep to penetrate the stratum corneum, but not deep enough to disturb the dermis. The skin of the other two rabbits remained intact.
Behavioural reactions were recorded during the 24 hr exposure period.
The plastic wrapping was removed from the rabbits at the end of the 24 hr exposure period. The exposure sites were examined for local reactions. Observations for mortality and behavioural abnormalities were made for a further 14 days. Special emphasis was placed on observation for skin irritation reactions at 24 and 72 hours after test material application. - Statistics:
- Not applicable.
Results and discussion
- Preliminary study:
- No preliminary study reported.
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 10 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: No deaths
- Mortality:
- No mortalities occurred.
- Clinical signs:
- other: No data.
- Gross pathology:
- No data.
- Other findings:
- No other findings reported.
Any other information on results incl. tables
The authors state that the study provides no evidence for percutaneous absorption of pentaerythritol through intact and abraded rabbit skin, however equally the absence of findings could be interpreted as reflecting the inherently low toxicity of the substance.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Pentaerythritol was found to be of low acute dermal toxicity. The acute dermal LD50 of pentaerythritol in rabbits was found to be >10 g/kg bw in rabbits under the conditions of this study.
- Executive summary:
The acute dermal toxicity of pentaerythritol was determined in four New Zealand White rabbits (2 male and 2 female). The test sites were clipped free of hair 24 hours prior to application. Immediately prior to application, the test site of 1 male rabbit and 1 female rabbit was abraded; the other two rabbits remained intact. The test substance was applied as an aqueous paste at a dose of 10 g/kg, and held in contact with the skin for 24 hours under an impervious plastic dressing. The acute dermal LD50 of pentaerythritol in rabbits was found to be >10 g/kg bw in rabbits under the conditions of this study. The authors state that the study provides no evidence for percutaneous absorption of pentaerythritol through intact and abraded rabbit skin, however equally the absence of findings could be interpreted as reflecting the inherently low toxicity of the substance.
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