Registration Dossier
Registration Dossier
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EC number: 200-662-2 | CAS number: 67-64-1
Additional toxicological data
Administrative data
- Endpoint:
- additional toxicological information
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Studies meet generally accepted scientific principles, sufficient documentation; data acceptable for weight of evidence approach
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Quantitative studies of in vitro transformation by chemical carcinogens
- Author:
- DiPaolo JA, Donovan P, Nelson R
- Year:
- 1 969
- Bibliographic source:
- J Nat Cancer Inst 42: 867-876
- Reference Type:
- publication
- Title:
- Transformation of cell cultures as an indication of the carcinogenic potential of chemicals
- Author:
- Freeman AE, Weisburger EK, Weisburger JH, Wolford RG, Maryak JM, Huebner RJ
- Year:
- 1 973
- Bibliographic source:
- J Nat Cancer Inst 51: 799-808
- Reference Type:
- publication
- Title:
- Transformation of Syrian hamster embryo cells by diverse chemicals and correlation with their reported carcinogenic and mutagenic activities
- Author:
- Pienta RJ
- Year:
- 1 980
- Bibliographic source:
- Chem Mutagens 6: 175-202
- Reference Type:
- publication
- Title:
- Simultaneous determination of cellular mutagenesis and transformation by chemical carcinogens in Fischer rat embryo cells
- Author:
- Mishra NK, Wilson CM, Pant KJ, Thomas FO
- Year:
- 1 978
- Bibliographic source:
- J Toxicol Environ Health 4: 79-91
Materials and methods
- Type of study / information:
- Cell transformation assay
- Principles of method if other than guideline:
- Cultures of Syrian hamster embryo cells or rat embryo cells were treated with pure acetone, used as solvent for other chemicals, and cell transforming activity was determined for this solvent control.
Test material
- Reference substance name:
- Acetone
- EC Number:
- 200-662-2
- EC Name:
- Acetone
- Cas Number:
- 67-64-1
- Molecular formula:
- C3H6O
- IUPAC Name:
- propan-2-one
Constituent 1
Results and discussion
Any other information on results incl. tables
Acetone was inactive in several cell transformation assays with cultures of Syrian hamster embryo cells or rat embryo cells.
Applicant's summary and conclusion
- Conclusions:
- Acetone, that has been used as solvent for other chemicals, showed absence of cell transforming activity in solvent control assays with cultures of Syrian hamster embryo cells or rat embryo cells.
- Executive summary:
Acetone has been used as solvent for other chemicals in several cell transformation assays with cultures of Syrian hamster embryo cells or rat embryo cells. Assays with pure acetone as solvent control showed absence of cell transforming activity of acetone .
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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